ID   HBA_ANSAN               Reviewed;         142 AA.
AC   P01989;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Hemoglobin subunit alpha-A;
DE   AltName: Full=Alpha-A-globin;
DE   AltName: Full=Hemoglobin alpha-A chain;
GN   Name=HBAA;
OS   Anser anser anser (Western greylag goose).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anserinae; Anser.
OX   NCBI_TaxID=8844;
RN   [1]
RP   PROTEIN SEQUENCE OF 2-142.
RX   PubMed=7346378;
RA   Oberthur W., Braunitzer G., Kalas S.;
RT   "Hemoglobins, XLII. Studies on the hemoglobin of the greylag goose (Anser
RT   anser). The primary structures of the alpha- and beta-chains of the main
RT   component.";
RL   Hoppe-Seyler's Z. Physiol. Chem. 362:1101-1112(1981).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (3.09 ANGSTROMS).
RX   PubMed=11717498; DOI=10.1107/s0907444901016493;
RA   Liang Y.H., Liu X.Z., Liu S.H., Lu G.Y.;
RT   "The structure of greylag goose oxy haemoglobin: the roles of four
RT   mutations compared with bar-headed goose haemoglobin.";
RL   Acta Crystallogr. D 57:1850-1856(2001).
CC   -!- FUNCTION: Involved in oxygen transport from the lung to the various
CC       peripheral tissues.
CC   -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC   -!- TISSUE SPECIFICITY: Red blood cells.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   PIR; A02310; HAGS.
DR   PDB; 1FAW; X-ray; 3.09 A; A/C=2-142.
DR   PDBsum; 1FAW; -.
DR   AlphaFoldDB; P01989; -.
DR   SMR; P01989; -.
DR   EvolutionaryTrace; P01989; -.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd08927; Hb-alpha-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002338; Hemoglobin_a-typ.
DR   InterPro; IPR002339; Hemoglobin_pi.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00612; ALPHAHAEM.
DR   PRINTS; PR00815; PIHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Direct protein sequencing; Heme; Iron; Metal-binding;
KW   Oxygen transport; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..142
FT                   /note="Hemoglobin subunit alpha-A"
FT                   /id="PRO_0000052551"
FT   BINDING         59
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT   BINDING         88
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT   HELIX           5..16
FT                   /evidence="ECO:0007829|PDB:1FAW"
FT   HELIX           19..21
FT                   /evidence="ECO:0007829|PDB:1FAW"
FT   HELIX           22..36
FT                   /evidence="ECO:0007829|PDB:1FAW"
FT   HELIX           38..43
FT                   /evidence="ECO:0007829|PDB:1FAW"
FT   HELIX           54..71
FT                   /evidence="ECO:0007829|PDB:1FAW"
FT   HELIX           74..76
FT                   /evidence="ECO:0007829|PDB:1FAW"
FT   TURN            77..81
FT                   /evidence="ECO:0007829|PDB:1FAW"
FT   HELIX           82..89
FT                   /evidence="ECO:0007829|PDB:1FAW"
FT   HELIX           97..113
FT                   /evidence="ECO:0007829|PDB:1FAW"
FT   HELIX           115..117
FT                   /evidence="ECO:0007829|PDB:1FAW"
FT   HELIX           120..137
FT                   /evidence="ECO:0007829|PDB:1FAW"
FT   HELIX           138..141
FT                   /evidence="ECO:0007829|PDB:1FAW"
SQ   SEQUENCE   142 AA;  15436 MW;  A843FE1FB8A57D05 CRC64;
     MVLSAADKTN VKGVFSKIGG HAEEYGAETL ERMFTAYPQT KTYFPHFDLQ HGSAQIKAHG
     KKVAAALVEA VNHIDDIAGA LSKLSDLHAQ KLRVDPVNFK FLGHCFLVVV AIHHPSALTP
     EVHASLDKFL CAVGTVLTAK YR