ID   HBA_ANSIN               Reviewed;         142 AA.
AC   P01990;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Hemoglobin subunit alpha-A;
DE   AltName: Full=Alpha-A-globin;
DE   AltName: Full=Hemoglobin alpha-A chain;
GN   Name=HBAA;
OS   Anser indicus (Bar-headed goose) (Anas indica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anserinae; Anser.
OX   NCBI_TaxID=8846;
RN   [1]
RP   PROTEIN SEQUENCE OF 2-142.
RX   PubMed=7106705;
RA   Oberthur W., Braunitzer G., Wurdinger I.;
RT   "Hemoglobins, XLVII. Hemoglobins of the bar-headed goose (Anser indicus):
RT   primary structure and physiology of respiration, systematic and
RT   evolution.";
RL   Hoppe-Seyler's Z. Physiol. Chem. 363:581-590(1982).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
RX   PubMed=8568892; DOI=10.1006/jmbi.1996.0040;
RA   Zhang J., Hua Z., Tame J.R.H., Lu G., Zhang R., Gu X.;
RT   "The crystal structure of a high oxygen affinity species of haemoglobin
RT   (bar-headed goose haemoglobin in the oxy form).";
RL   J. Mol. Biol. 255:484-493(1996).
CC   -!- FUNCTION: Involved in oxygen transport from the lung to the various
CC       peripheral tissues.
CC   -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC   -!- TISSUE SPECIFICITY: Red blood cells.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   PIR; A02311; HAGSI.
DR   PDB; 1A4F; X-ray; 2.00 A; A=2-142.
DR   PDB; 1C40; X-ray; 2.30 A; A=2-142.
DR   PDB; 1HV4; X-ray; 2.80 A; A/C/E/G=2-142.
DR   PDBsum; 1A4F; -.
DR   PDBsum; 1C40; -.
DR   PDBsum; 1HV4; -.
DR   AlphaFoldDB; P01990; -.
DR   SMR; P01990; -.
DR   MINT; P01990; -.
DR   EvolutionaryTrace; P01990; -.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd08927; Hb-alpha-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002338; Hemoglobin_a-typ.
DR   InterPro; IPR002339; Hemoglobin_pi.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00612; ALPHAHAEM.
DR   PRINTS; PR00815; PIHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Direct protein sequencing; Heme; Iron; Metal-binding;
KW   Oxygen transport; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..142
FT                   /note="Hemoglobin subunit alpha-A"
FT                   /id="PRO_0000052552"
FT   BINDING         59
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT   BINDING         88
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT   HELIX           5..18
FT                   /evidence="ECO:0007829|PDB:1A4F"
FT   HELIX           22..36
FT                   /evidence="ECO:0007829|PDB:1A4F"
FT   HELIX           38..43
FT                   /evidence="ECO:0007829|PDB:1A4F"
FT   HELIX           54..71
FT                   /evidence="ECO:0007829|PDB:1A4F"
FT   TURN            72..75
FT                   /evidence="ECO:0007829|PDB:1A4F"
FT   HELIX           77..80
FT                   /evidence="ECO:0007829|PDB:1A4F"
FT   HELIX           82..89
FT                   /evidence="ECO:0007829|PDB:1A4F"
FT   HELIX           97..113
FT                   /evidence="ECO:0007829|PDB:1A4F"
FT   TURN            115..117
FT                   /evidence="ECO:0007829|PDB:1A4F"
FT   HELIX           120..136
FT                   /evidence="ECO:0007829|PDB:1A4F"
FT   HELIX           139..141
FT                   /evidence="ECO:0007829|PDB:1C40"
SQ   SEQUENCE   142 AA;  15468 MW;  3E1691F128B173F0 CRC64;
     MVLSAADKTN VKGVFSKISG HAEEYGAETL ERMFTAYPQT KTYFPHFDLQ HGSAQIKAHG
     KKVVAALVEA VNHIDDIAGA LSKLSDLHAQ KLRVDPVNFK FLGHCFLVVV AIHHPSALTA
     EVHASLDKFL CAVGTVLTAK YR