AN20B_HUMAN
ID AN20B_HUMAN Reviewed; 823 AA.
AC Q5CZ79; A6NC18;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 2.
DT 25-MAY-2022, entry version 98.
DE RecName: Full=Ankyrin repeat domain-containing protein 20B;
DE AltName: Full=Ankyrin repeat domain-containing protein 20A pseudogene;
GN Name=ANKRD20A8P; Synonyms=ANKRD20B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5CZ79-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5CZ79-2; Sequence=VSP_032809, VSP_032810;
CC -!- SEQUENCE CAUTION:
CC Sequence=CAI56787.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC073464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC097374; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR936649; CAI56787.1; ALT_INIT; mRNA.
DR AlphaFoldDB; Q5CZ79; -.
DR SMR; Q5CZ79; -.
DR iPTMnet; Q5CZ79; -.
DR PhosphoSitePlus; Q5CZ79; -.
DR BioMuta; ANKRD20A8P; -.
DR DMDM; 182627628; -.
DR EPD; Q5CZ79; -.
DR jPOST; Q5CZ79; -.
DR MassIVE; Q5CZ79; -.
DR MaxQB; Q5CZ79; -.
DR PeptideAtlas; Q5CZ79; -.
DR PRIDE; Q5CZ79; -.
DR ProteomicsDB; 62729; -. [Q5CZ79-1]
DR ProteomicsDB; 62730; -. [Q5CZ79-2]
DR GeneCards; ANKRD20A8P; -.
DR HGNC; HGNC:23666; ANKRD20A8P.
DR neXtProt; NX_Q5CZ79; -.
DR InParanoid; Q5CZ79; -.
DR PhylomeDB; Q5CZ79; -.
DR ChiTaRS; ANKRD20A8P; human.
DR Pharos; Q5CZ79; Tdark.
DR PRO; PR:Q5CZ79; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q5CZ79; protein.
DR Gene3D; 1.25.40.20; -; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR039497; CC144C-like_CC_dom.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF14915; CCDC144C; 1.
DR SMART; SM00248; ANK; 6.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 4.
PE 2: Evidence at transcript level;
KW Alternative splicing; ANK repeat; Coiled coil; Reference proteome; Repeat.
FT CHAIN 1..823
FT /note="Ankyrin repeat domain-containing protein 20B"
FT /id="PRO_0000328835"
FT REPEAT 32..65
FT /note="ANK 1"
FT REPEAT 66..95
FT /note="ANK 2"
FT REPEAT 99..128
FT /note="ANK 3"
FT REPEAT 132..161
FT /note="ANK 4"
FT REPEAT 165..194
FT /note="ANK 5"
FT REPEAT 198..227
FT /note="ANK 6"
FT REGION 302..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 355..401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 431..480
FT /evidence="ECO:0000255"
FT COILED 565..724
FT /evidence="ECO:0000255"
FT COILED 776..805
FT /evidence="ECO:0000255"
FT COMPBIAS 366..386
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..401
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..428
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_032809"
FT VAR_SEQ 429..439
FT /note="FPKKLKEEHDK -> MNFKINVFICR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_032810"
FT CONFLICT 618
FT /note="G -> C (in Ref. 2; CAI56787)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 823 AA; 93909 MW; 42F58A41BEB97330 CRC64;
MKLFGFGSRR GQTAEGSIDH VYTGSGYRIR DSELQKIHRA AVKGDAAEVE RCLARRSGDL
DARDKQHRTA LHLACASGHV QVVTLLVNRK CQIDICDKEN RTPLIQAVHC QEEACAVILL
KHGANPNLKD IYGNTALHYA VYSESTSLAE KLLSHGAHIE ALDKDSNTPL LFAIICKKEK
MVEFLLKKKA STHAVDRLRR SALMLAVYYD SPGIVSILLK QNIDVFAQDM CGRDAEDYAI
SHHLTKIQQQ ILEHKQKILK KEKSDVGSSD ESAVSIFHEL RVDSLPASDD KDLSVATKQC
VPEKVSEPLP GPSHEKGNRI VNGQGEGPPA KHPSLKPTTG VEDPAVKGAV QRKNVQTLRA
EQALPVASEE EQERHERSEK KQPQVKKGNN TNKSEKIQLS ENICDSTSSA AAGRLTQQRK
IGKTYPQQFP KKLKEEHDKC TLKQENEEKT NVNMLYKKNR EELERKEKQY KKEVEAKQLE
PTVQSLEMKS KTARNTPNRD FHNHEETKGL MDENCILKAD IAILRQEICT MKNDNLEKEN
KYLKDIKIVK ETNAALEKYI KLNEEMITET AFRYQQELND LKAENTRLNA ELLKEKESKK
RLEADIESYQ SRLAAAIGKH SESVKTERNV KLALERTQDV SVQVEMSSAI SKVKDENEFL
TEQLSETQIK FNALKDKFRK TRDSLRKKSL ALETVQNDLR KTQQQTQEMK EMYQNAEAKV
NNSTGKWNCV EERICHLQRE NAWLVQQLDD VHQKEDHKEI VTNIQRGFIE SGKKDLVLEE
KSKKLMNECD HLKESLFQYE REKAEGVVSI KEDKYFQTSR KKI
