ID   HBA_CAICR               Reviewed;         141 AA.
AC   P02000;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Hemoglobin subunit alpha;
DE   AltName: Full=Alpha-globin;
DE   AltName: Full=Hemoglobin alpha chain;
GN   Name=HBA;
OS   Caiman crocodilus (Spectacled caiman) (Caiman sclerops).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Caimaninae; Caiman.
OX   NCBI_TaxID=8499;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=6286445;
RA   Leclercq F., Schnek A.G., Braunitzer G., Stangl A., Schrank B.;
RT   "Direct reciprocal allosteric interaction of oxygen and hydrogen carbonate
RT   sequence of the haemoglobins of the Caiman (Caiman crocodylus), the Nile
RT   crocodile (Crocodylus niloticus) and the Mississippi crocodile (Alligator
RT   mississippiensis).";
RL   Hoppe-Seyler's Z. Physiol. Chem. 362:1151-1158(1981).
CC   -!- FUNCTION: Involved in oxygen transport from the lung to the various
CC       peripheral tissues.
CC   -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC   -!- TISSUE SPECIFICITY: Red blood cells.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   PIR; A02321; HACQ.
DR   AlphaFoldDB; P02000; -.
DR   SMR; P02000; -.
DR   PRIDE; P02000; -.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd08927; Hb-alpha-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002338; Hemoglobin_a-typ.
DR   InterPro; IPR002339; Hemoglobin_pi.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00612; ALPHAHAEM.
DR   PRINTS; PR00815; PIHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW   Transport.
FT   CHAIN           1..141
FT                   /note="Hemoglobin subunit alpha"
FT                   /id="PRO_0000052575"
FT   BINDING         58
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT   BINDING         87
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
SQ   SEQUENCE   141 AA;  15767 MW;  671B4C10C474238B CRC64;
     VLSEEDKSHV KAIWGKVAGH LEEYGAEALE RMFCAYPQTK IYFPHFDMSH NSAQIRGHGK
     KVFAALHDAV NHIDDLAGAL CRLSDLHAHN LRVDPVNFKF LSQCILVVFG VHHPCSLTPE
     VHASLDKFLC AVSAMLTSKY R