HBA_CHICK
ID HBA_CHICK Reviewed; 142 AA.
AC P01994; Q9PWP3;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Hemoglobin subunit alpha-A;
DE AltName: Full=Alpha-A-globin;
DE AltName: Full=Hemoglobin alpha-A chain;
GN Name=HBAA;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=White leghorn;
RX PubMed=1656392; DOI=10.1093/nar/19.19.5321;
RA Lewis W., Lee J.D., Dodgson J.B.;
RT "Adult chicken alpha-globin gene expression in transfected QT6 quail cells:
RT evidence for a negative regulatory element in the alpha D gene region.";
RL Nucleic Acids Res. 19:5321-5329(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=7057930; DOI=10.1038/295710a0;
RA Knoechel W., Wittig B., Wittig S., John M.E., Grundmann U., Oberthur W.,
RA Godovac J., Braunitzer G.;
RT "No evidence for 'stress' alpha-globin genes in chicken.";
RL Nature 295:710-712(1982).
RN [3]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=6300093; DOI=10.1016/s0021-9258(18)32669-3;
RA Dodgson J.B., Engel J.D.;
RT "The nucleotide sequence of the adult chicken alpha-globin genes.";
RL J. Biol. Chem. 258:4623-4629(1983).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6273837; DOI=10.1073/pnas.78.10.5998;
RA Dodgson J.B., McCune K.C., Rusling D.J., Krust A., Engel J.D.;
RT "Adult chicken alpha-globin genes alpha A and alpha D: no anemic shock
RT alpha-globin exists in domestic chickens.";
RL Proc. Natl. Acad. Sci. U.S.A. 78:5998-6002(1981).
RN [5]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=6251083; DOI=10.1016/s0021-9258(19)70562-6;
RA Richards R.I., Wells J.R.E.;
RT "Chicken globin genes. Nucleotide sequence of cDNA clones coding for the
RT alpha-globin expressed during hemolytic anemia.";
RL J. Biol. Chem. 255:9306-9311(1980).
RN [6]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=6894907; DOI=10.1016/0378-1119(81)90020-2;
RA Liu A.Y., Salser W.;
RT "Complete nucleotide sequence of a chicken alpha-globin cDNA.";
RL Gene 13:409-415(1981).
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=6253930; DOI=10.1093/nar/8.6.1187;
RA Deacon N.J., Shine J., Naora H.;
RT "Complete nucleotide sequence of a cloned chicken alpha-globin cDNA.";
RL Nucleic Acids Res. 8:1187-1199(1980).
RN [8]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11157800; DOI=10.1093/hmg/10.4.371;
RA Flint J., Tufarelli C., Peden J., Clark K., Daniels R.J., Hardison R.,
RA Miller W., Philipsen S., Tan-Un K.C., McMorrow T., Frampton J., Alter B.P.,
RA Frischauf A.-M., Higgs D.R.;
RT "Comparative genome analysis delimits a chromosomal domain and identifies
RT key regulatory elements in the alpha globin cluster.";
RL Hum. Mol. Genet. 10:371-382(2001).
RN [9]
RP NUCLEOTIDE SEQUENCE.
RA Zhao Z., Sjakste N., De Moura-Gallo C.V., Ioudinkova E.S., Razin S.V.,
RA Scherrer K.;
RT "Organization of the chicken domain of alpha-globin genes.";
RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
RN [10]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 12-111.
RC STRAIN=White leghorn;
RA Fehrer J.;
RT "Easy access to the alpha-A-globin gene of galliform birds by EPIC-PCR.";
RL Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
RN [11]
RP NUCLEOTIDE SEQUENCE OF 61-84.
RX PubMed=714170; DOI=10.1038/276418a0;
RA Cummings I.W., Liu A.Y., Salser W.A.;
RT "Identification of a new chicken alpha-globin structural gene by
RT complementary DNA cloning.";
RL Nature 276:418-419(1978).
RN [12]
RP PRELIMINARY PROTEIN SEQUENCE OF 2-142.
RX PubMed=4567660;
RA Matsuda G., Takei H., Wu K.C., Shiozawa T., Ota Y.;
RT "Sequence studies on the tryptic peptides and the chymotryptic peptides
RT from the alpha polypeptide chain of aII component of the chicken
RT hemoglobin. Biochemical studies on hemoglobins and myoglobins. 8.";
RL Int. J. Pept. Protein Res. 4:291-302(1972).
CC -!- FUNCTION: Involved in oxygen transport from the lung to the various
CC peripheral tissues.
CC -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC -!- TISSUE SPECIFICITY: Red blood cells.
CC -!- MISCELLANEOUS: This alpha chain is from the adult major tetrameric
CC component, which has been called hemoglobin A or AII.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X59989; CAA42606.1; -; Genomic_DNA.
DR EMBL; V00379; CAA23678.1; -; mRNA.
DR EMBL; V00380; CAA23679.1; -; mRNA.
DR EMBL; V00410; CAA23701.1; -; Genomic_DNA.
DR EMBL; M15379; AAA48582.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AY016020; AAL35404.1; -; Genomic_DNA.
DR EMBL; AF098919; AAM09073.1; -; Genomic_DNA.
DR EMBL; AF125311; AAD32581.1; -; Genomic_DNA.
DR EMBL; M35068; AAA48583.1; -; mRNA.
DR PIR; S18673; HACH2.
DR RefSeq; NP_001004376.1; NM_001004376.3.
DR PDB; 3BEV; X-ray; 2.10 A; C=20-30.
DR PDB; 5AD0; X-ray; 2.84 A; C=20-30.
DR PDBsum; 3BEV; -.
DR PDBsum; 5AD0; -.
DR AlphaFoldDB; P01994; -.
DR SMR; P01994; -.
DR STRING; 9031.ENSGALP00000038904; -.
DR PaxDb; P01994; -.
DR Ensembl; ENSGALT00000075828; ENSGALP00000050043; ENSGALG00000043234.
DR GeneID; 416652; -.
DR KEGG; gga:416652; -.
DR CTD; 3039; -.
DR VEuPathDB; HostDB:geneid_416652; -.
DR eggNOG; KOG3378; Eukaryota.
DR GeneTree; ENSGT00940000154590; -.
DR HOGENOM; CLU_003827_10_2_1; -.
DR InParanoid; P01994; -.
DR OMA; ARMFIAY; -.
DR OrthoDB; 1398217at2759; -.
DR PhylomeDB; P01994; -.
DR Reactome; R-GGA-1237044; Erythrocytes take up carbon dioxide and release oxygen.
DR Reactome; R-GGA-1247673; Erythrocytes take up oxygen and release carbon dioxide.
DR Reactome; R-GGA-2168880; Scavenging of heme from plasma.
DR Reactome; R-GGA-9707564; Cytoprotection by HMOX1.
DR Reactome; R-GGA-9707616; Heme signaling.
DR EvolutionaryTrace; P01994; -.
DR PRO; PR:P01994; -.
DR Proteomes; UP000000539; Chromosome 14.
DR Bgee; ENSGALG00000043234; Expressed in lung and 12 other tissues.
DR GO; GO:0005615; C:extracellular space; IDA:AgBase.
DR GO; GO:0031838; C:haptoglobin-hemoglobin complex; IBA:GO_Central.
DR GO; GO:0005833; C:hemoglobin complex; IBA:GO_Central.
DR GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0043177; F:organic acid binding; IBA:GO_Central.
DR GO; GO:0019825; F:oxygen binding; IBA:GO_Central.
DR GO; GO:0005344; F:oxygen carrier activity; IBA:GO_Central.
DR GO; GO:0098869; P:cellular oxidant detoxification; IEA:GOC.
DR GO; GO:0042744; P:hydrogen peroxide catabolic process; IBA:GO_Central.
DR CDD; cd08927; Hb-alpha-like; 1.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002338; Hemoglobin_a-typ.
DR InterPro; IPR002339; Hemoglobin_pi.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00612; ALPHAHAEM.
DR PRINTS; PR00815; PIHAEM.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Heme; Iron; Metal-binding;
KW Oxygen transport; Reference proteome; Transport.
FT INIT_MET 1
FT /note="Removed"
FT CHAIN 2..142
FT /note="Hemoglobin subunit alpha-A"
FT /id="PRO_0000052599"
FT BINDING 59
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT BINDING 88
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
FT CONFLICT 90
FT /note="H -> D (in Ref. 10; AAD32581)"
FT /evidence="ECO:0000305"
FT CONFLICT 93..95
FT /note="RVD -> TGG (in Ref. 7; CAA23678)"
FT /evidence="ECO:0000305"
FT CONFLICT 111
FT /note="A -> T (in Ref. 6)"
FT /evidence="ECO:0000305"
FT CONFLICT 121
FT /note="E -> K (in Ref. 7; CAA23678)"
FT /evidence="ECO:0000305"
FT CONFLICT 122
FT /note="V -> I (in Ref. 6)"
FT /evidence="ECO:0000305"
FT CONFLICT 128
FT /note="K -> N (in Ref. 7; CAA23678)"
FT /evidence="ECO:0000305"
FT HELIX 25..28
FT /evidence="ECO:0007829|PDB:3BEV"
SQ SEQUENCE 142 AA; 15429 MW; 56847D9227928E2F CRC64;
MVLSAADKNN VKGIFTKIAG HAEEYGAETL ERMFTTYPPT KTYFPHFDLS HGSAQIKGHG
KKVVAALIEA ANHIDDIAGT LSKLSDLHAH KLRVDPVNFK LLGQCFLVVV AIHHPAALTP
EVHASLDKFL CAVGTVLTAK YR
