HBA_CRONI
ID HBA_CRONI Reviewed; 141 AA.
AC P01998;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Hemoglobin subunit alpha;
DE AltName: Full=Alpha-globin;
DE AltName: Full=Hemoglobin alpha chain;
GN Name=HBA;
OS Crocodylus niloticus (Nile crocodile) (African crocodile).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Longirostres; Crocodylidae;
OC Crocodylus.
OX NCBI_TaxID=8501;
RN [1]
RP PROTEIN SEQUENCE.
RX PubMed=6286445;
RA Leclercq F., Schnek A.G., Braunitzer G., Stangl A., Schrank B.;
RT "Direct reciprocal allosteric interaction of oxygen and hydrogen carbonate
RT sequence of the haemoglobins of the Caiman (Caiman crocodylus), the Nile
RT crocodile (Crocodylus niloticus) and the Mississippi crocodile (Alligator
RT mississippiensis).";
RL Hoppe-Seyler's Z. Physiol. Chem. 362:1151-1158(1981).
CC -!- FUNCTION: Involved in oxygen transport from the lung to the various
CC peripheral tissues.
CC -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC -!- TISSUE SPECIFICITY: Red blood cells.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR PIR; A02319; HAAK.
DR AlphaFoldDB; P01998; -.
DR SMR; P01998; -.
DR GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR CDD; cd08927; Hb-alpha-like; 1.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002338; Hemoglobin_a-typ.
DR InterPro; IPR002339; Hemoglobin_pi.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00612; ALPHAHAEM.
DR PRINTS; PR00815; PIHAEM.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW Transport.
FT CHAIN 1..141
FT /note="Hemoglobin subunit alpha"
FT /id="PRO_0000052610"
FT BINDING 58
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT BINDING 87
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
SQ SEQUENCE 141 AA; 15574 MW; B27FD545835C121C CRC64;
VLSSDDKCNV KAVWSKVAGH LEEYGAEALE RMFCAYPQTK IYFPHFDLSH GSAQIRAHGK
KVFAALHEAV NHIDDLPGAL CRLSELHAHS LRVDPVNFKF LAQCVLVVVA IHHPGSLTPE
VHASLDKFLC AVSSVLTSKY R