ID   HBA_CYPCA               Reviewed;         143 AA.
AC   P02016;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Hemoglobin subunit alpha;
DE   AltName: Full=Alpha-globin;
DE   AltName: Full=Hemoglobin alpha chain;
GN   Name=hba;
OS   Cyprinus carpio (Common carp).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Cyprinus.
OX   NCBI_TaxID=7962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=6548931; DOI=10.1016/0167-4781(84)90037-x;
RA   Takeshita S., Aoki T., Fukumaki Y., Takagi Y.;
RT   "Cloning and sequence analysis of a cDNA for the alpha-globin mRNA of carp,
RT   Cyprinus carpio.";
RL   Biochim. Biophys. Acta 783:265-271(1984).
RN   [2]
RP   PROTEIN SEQUENCE OF 2-143, AND ACETYLATION AT SER-2.
RX   PubMed=4875309;
RA   Hilse K., Braunitzer G.;
RT   "Hemoglobin, XVI. Amino acid sequence of the alpha-chain of both main
RT   components of carp hemoglobin.";
RL   Hoppe-Seyler's Z. Physiol. Chem. 349:433-450(1968).
CC   -!- FUNCTION: Involved in oxygen transport from gills to the various
CC       peripheral tissues.
CC   -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC   -!- TISSUE SPECIFICITY: Red blood cells.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   EMBL; M25643; AAA49202.1; -; mRNA.
DR   PIR; I50491; HACA.
DR   AlphaFoldDB; P02016; -.
DR   SMR; P02016; -.
DR   iPTMnet; P02016; -.
DR   Proteomes; UP000694384; Unplaced.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd08927; Hb-alpha-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002338; Hemoglobin_a-typ.
DR   InterPro; IPR002339; Hemoglobin_pi.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00612; ALPHAHAEM.
DR   PRINTS; PR00815; PIHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Direct protein sequencing; Heme; Iron; Metal-binding;
KW   Oxygen transport; Reference proteome; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:4875309"
FT   CHAIN           2..143
FT                   /note="Hemoglobin subunit alpha"
FT                   /id="PRO_0000052615"
FT   BINDING         60
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT   BINDING         89
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000269|PubMed:4875309"
FT   CONFLICT        13..14
FT                   /note="GL -> IA (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        59..61
FT                   /note="KHG -> HGK (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        84
FT                   /note="A -> S (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        91
FT                   /note="F -> S (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        105..115
FT                   /note="HNVIVVIGMLY -> NHIVVGIMFYL (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   143 AA;  15447 MW;  19D963BC7E6AEB25 CRC64;
     MSLSDKDKAA VKGLWAKISP KADDIGAEAL GRMLTVYPQT KTYFAHWADL SPGSGPVKKH
     GKVIMGAVGD AVSKIDDLVG GLAALSELHA FKLRVDPANF KILAHNVIVV IGMLYPGDFP
     PEVHMSVDKF FQNLALALSE KYR