HBA_LEPPA
ID HBA_LEPPA Reviewed; 143 AA.
AC P02020;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Hemoglobin subunit alpha;
DE AltName: Full=Alpha-globin;
DE AltName: Full=Hemoglobin alpha chain;
GN Name=HBA;
OS Lepidosiren paradoxus (South American lungfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Dipnomorpha; Ceratodontiformes; Lepidosirenoidei; Lepidosirenidae;
OC Lepidosiren.
OX NCBI_TaxID=7883;
RN [1]
RP PROTEIN SEQUENCE.
RX PubMed=6090299; DOI=10.1515/bchm2.1984.365.1.639;
RA Rodewald K., Stangl A., Braunitzer G.;
RT "Primary structure, biochemical and physiological aspects of hemoglobin
RT from South American lungfish (Lepidosiren paradoxus, Dipnoi).";
RL Hoppe-Seyler's Z. Physiol. Chem. 365:639-649(1984).
CC -!- FUNCTION: Involved in oxygen transport from the lung to the various
CC peripheral tissues.
CC -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC -!- TISSUE SPECIFICITY: Red blood cells.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
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DR PIR; A02349; HALUA.
DR AlphaFoldDB; P02020; -.
DR SMR; P02020; -.
DR GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR CDD; cd08927; Hb-alpha-like; 1.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002338; Hemoglobin_a-typ.
DR Pfam; PF00042; Globin; 1.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW Transport.
FT CHAIN 1..143
FT /note="Hemoglobin subunit alpha"
FT /id="PRO_0000052667"
FT BINDING 60
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT BINDING 89
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
SQ SEQUENCE 143 AA; 16092 MW; 54E0C28213051123 CRC64;
MRFSQDDEVL IKEAWGLLHQ IPNAGGEALA RMFSCYPGTK SYFPHFGHDF SANNEKVKHH
GKKVVDAIGQ GVQHLHDLSS CLHTLSEKHA RELMVDPCNF QYLIEAIMTT IAAHYGEKFT
PEINCAAEKC LGQIVHVLIS LYR