ID   AN32A_DANRE             Reviewed;         254 AA.
AC   Q7ZUP0;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Acidic leucine-rich nuclear phosphoprotein 32 family member A;
GN   Name=anp32a; ORFNames=zgc:55516;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB; TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=15895553; DOI=10.1080/14734220410019020;
RA   Matilla A., Radrizzani M.;
RT   "The Anp32 family of proteins containing leucine-rich repeats.";
RL   Cerebellum 4:7-18(2005).
CC   -!- FUNCTION: Implicated in a number of cellular processes, including
CC       proliferation, differentiation, caspase-dependent and caspase-
CC       independent apoptosis, suppression of transformation (tumor
CC       suppressor), inhibition of protein phosphatase 2A, regulation of mRNA
CC       trafficking and stability, and inhibition of acetyltransferases as part
CC       of the INHAT (inhibitor of histone acetyltransferases) complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Endoplasmic reticulum {ECO:0000250}.
CC   -!- PTM: Phosphorylated on serine residues. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ANP32 family. {ECO:0000305}.
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DR   EMBL; BC048047; AAH48047.1; -; mRNA.
DR   EMBL; BC071357; AAH71357.1; -; mRNA.
DR   RefSeq; NP_956280.1; NM_199986.1.
DR   AlphaFoldDB; Q7ZUP0; -.
DR   SMR; Q7ZUP0; -.
DR   STRING; 7955.ENSDARP00000097644; -.
DR   PaxDb; Q7ZUP0; -.
DR   PRIDE; Q7ZUP0; -.
DR   Ensembl; ENSDART00000008785; ENSDARP00000022360; ENSDARG00000006487.
DR   GeneID; 335907; -.
DR   KEGG; dre:335907; -.
DR   CTD; 8125; -.
DR   ZFIN; ZDB-GENE-030131-7850; anp32a.
DR   eggNOG; KOG2739; Eukaryota.
DR   GeneTree; ENSGT00950000182907; -.
DR   InParanoid; Q7ZUP0; -.
DR   OrthoDB; 1622194at2759; -.
DR   PhylomeDB; Q7ZUP0; -.
DR   TreeFam; TF317206; -.
DR   Reactome; R-DRE-450520; HuR (ELAVL1) binds and stabilizes mRNA.
DR   PRO; PR:Q7ZUP0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 7.
DR   Bgee; ENSDARG00000006487; Expressed in gastrula and 29 other tissues.
DR   ExpressionAtlas; Q7ZUP0; baseline.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0006913; P:nucleocytoplasmic transport; ISS:UniProtKB.
DR   GO; GO:0042981; P:regulation of apoptotic process; IBA:GO_Central.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR045081; AN32.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR003603; U2A'_phosphoprotein32A_C.
DR   PANTHER; PTHR11375; PTHR11375; 1.
DR   SMART; SM00446; LRRcap; 1.
DR   PROSITE; PS51450; LRR; 4.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Endoplasmic reticulum; Leucine-rich repeat; Nucleus;
KW   Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..254
FT                   /note="Acidic leucine-rich nuclear phosphoprotein 32 family
FT                   member A"
FT                   /id="PRO_0000240185"
FT   REPEAT          16..40
FT                   /note="LRR 1"
FT   REPEAT          43..64
FT                   /note="LRR 2"
FT   REPEAT          65..87
FT                   /note="LRR 3"
FT   REPEAT          89..110
FT                   /note="LRR 4"
FT   DOMAIN          123..161
FT                   /note="LRRCT"
FT   REGION          166..254
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        166..233
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   254 AA;  29091 MW;  B4F94468072DC6BA CRC64;
     MDMKKRIHLE LRNRTPSDVK ELVLDNCRSN EGKIEGLTDE FEELEFLSTI NVGLTSVTNL
     PKLNKLKKLE LSDNRISGGL EVLAGKCPNL THLNLSGNKI KDLSTIEPLK KLESLKSLDL
     FNCEVTNLND YRENVFKLLP QLTYLDGYDK EDKEAPDSDA EAYVEGLDDE DDEEDEGEEE
     DYDEDAAPGE EDEEEGEEDD EEEGEEEEEE DISGEEEEEE ELNDGEVDDE EDFEEERGLK
     RKRELDEEGE EDDD