AN32A_DROME
ID AN32A_DROME Reviewed; 261 AA.
AC Q9V895; A2VEM0; Q0E936;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Acidic leucine-rich nuclear phosphoprotein 32 family member A;
GN Name=Anp32a; Synonyms=Mapmodulin; ORFNames=CG5784;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS A AND C).
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Kapadia B.,
RA Pacleb J.M., Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.;
RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15895553; DOI=10.1080/14734220410019020;
RA Matilla A., Radrizzani M.;
RT "The Anp32 family of proteins containing leucine-rich repeats.";
RL Cerebellum 4:7-18(2005).
CC -!- FUNCTION: Implicated in a number of cellular processes, including
CC proliferation, differentiation, caspase-dependent and caspase-
CC independent apoptosis, suppression of transformation (tumor
CC suppressor), inhibition of protein phosphatase 2A, regulation of mRNA
CC trafficking and stability, and inhibition of acetyltransferases as part
CC of the INHAT (inhibitor of histone acetyltransferases) complex.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Shuttles between nucleus
CC and cytoplasm. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=A;
CC IsoId=Q9V895-1; Sequence=Displayed;
CC Name=C;
CC IsoId=Q9V895-2; Sequence=VSP_036063;
CC -!- PTM: Phosphorylated on serine residues. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ANP32 family. {ECO:0000305}.
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DR EMBL; AE013599; AAF57776.1; -; Genomic_DNA.
DR EMBL; AE013599; ABV53838.1; -; Genomic_DNA.
DR EMBL; AY118324; AAM48353.1; -; mRNA.
DR EMBL; BT012474; AAS93745.1; -; mRNA.
DR EMBL; BT030189; ABN49328.1; -; mRNA.
DR RefSeq; NP_001097361.1; NM_001103891.3. [Q9V895-2]
DR RefSeq; NP_001163184.1; NM_001169713.2. [Q9V895-2]
DR RefSeq; NP_523780.1; NM_079056.4. [Q9V895-1]
DR RefSeq; NP_725732.1; NM_166258.3. [Q9V895-1]
DR AlphaFoldDB; Q9V895; -.
DR SMR; Q9V895; -.
DR BioGRID; 62728; 11.
DR IntAct; Q9V895; 2.
DR PaxDb; Q9V895; -.
DR DNASU; 37043; -.
DR EnsemblMetazoa; FBtr0086822; FBpp0086001; FBgn0034282. [Q9V895-1]
DR EnsemblMetazoa; FBtr0086823; FBpp0086002; FBgn0034282. [Q9V895-1]
DR EnsemblMetazoa; FBtr0113091; FBpp0112004; FBgn0034282. [Q9V895-2]
DR EnsemblMetazoa; FBtr0300410; FBpp0289639; FBgn0034282. [Q9V895-2]
DR GeneID; 37043; -.
DR KEGG; dme:Dmel_CG5784; -.
DR UCSC; CG5784-RA; d. melanogaster. [Q9V895-1]
DR UCSC; CG5784-RC; d. melanogaster.
DR CTD; 37043; -.
DR FlyBase; FBgn0034282; Mapmodulin.
DR VEuPathDB; VectorBase:FBgn0034282; -.
DR eggNOG; KOG2739; Eukaryota.
DR GeneTree; ENSGT00950000182907; -.
DR HOGENOM; CLU_063314_1_0_1; -.
DR InParanoid; Q9V895; -.
DR OMA; DKRSAFC; -.
DR PhylomeDB; Q9V895; -.
DR Reactome; R-DME-450520; HuR (ELAVL1) binds and stabilizes mRNA.
DR SignaLink; Q9V895; -.
DR BioGRID-ORCS; 37043; 0 hits in 3 CRISPR screens.
DR ChiTaRS; Mapmodulin; fly.
DR GenomeRNAi; 37043; -.
DR PRO; PR:Q9V895; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0034282; Expressed in cleaving embryo and 33 other tissues.
DR ExpressionAtlas; Q9V895; baseline and differential.
DR Genevisible; Q9V895; DM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; HDA:FlyBase.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0006913; P:nucleocytoplasmic transport; ISS:UniProtKB.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR045081; AN32.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR11375; PTHR11375; 1.
DR PROSITE; PS51450; LRR; 5.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Leucine-rich repeat; Nucleus;
KW Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..261
FT /note="Acidic leucine-rich nuclear phosphoprotein 32 family
FT member A"
FT /id="PRO_0000240188"
FT REPEAT 16..37
FT /note="LRR 1"
FT REPEAT 39..60
FT /note="LRR 2"
FT REPEAT 61..83
FT /note="LRR 3"
FT REPEAT 84..105
FT /note="LRR 4"
FT DOMAIN 118..156
FT /note="LRRCT"
FT REGION 145..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..186
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..228
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..261
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 170
FT /note="V -> DKCNAFCLNGLEIDLDELEAFEKRVKAKKSLQDKPPPQSEDKEVDEL
FT DEYLKELQLRESTDASTDEQSVINATPQPPSNSNLSFVILLYWFLAILNLGSATYF
FT (in isoform C)"
FT /evidence="ECO:0000303|Ref.4"
FT /id="VSP_036063"
SQ SEQUENCE 261 AA; 29176 MW; 18BC42BDDDAED2EE CRC64;
MEKRIELERR ARKVNQITEL NLDNCRSTSI VGLTDEYTAL ESLSLINVGL TTLKGFPKLP
NLKKLELSDN RISSGLNYLT TSPKLQYLNL SGNKIKDLET LKPLEEFKNL VVLDLFNNDA
TQVDNYREKI FKMLPSLNFL DGFDCNDEEV QSDGDDDDEV NGNDSDEVGV SDEDDDSDDS
DEEANGEVSL SEVYNDDLEE DNSDWEGEDE AGEEDEEEDS DIDDADGDAN ESAASVNAKD
KDGEKEADES QVRGKKRKHD G
