HBA_MELGA
ID HBA_MELGA Reviewed; 142 AA.
AC P81023;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Hemoglobin subunit alpha-A;
DE AltName: Full=Alpha-A-globin;
DE AltName: Full=Hemoglobin alpha-A chain;
GN Name=HBAA;
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103;
RN [1]
RP PROTEIN SEQUENCE OF 2-142.
RX PubMed=7576241;
RA Eguchi Y., Ikehara T., Kayo S., Eguchi T., Takei H.;
RT "Amino acid sequence of alpha- and beta-polypeptide chains of turkey
RT (Meleagris gallopavo) hemoglobin.";
RL Biol. Chem. Hoppe-Seyler 376:437-440(1995).
CC -!- FUNCTION: Involved in oxygen transport from the lung to the various
CC peripheral tissues.
CC -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC -!- TISSUE SPECIFICITY: Red blood cells.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
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DR PIR; S56102; S56102.
DR PDB; 2QMB; X-ray; 2.80 A; A/C=1-142.
DR PDB; 3K8B; X-ray; 2.30 A; A/C=2-142.
DR PDB; 6ZMX; X-ray; 1.39 A; A/C=2-142.
DR PDB; 6ZMY; X-ray; 1.66 A; A/C=2-142.
DR PDBsum; 2QMB; -.
DR PDBsum; 3K8B; -.
DR PDBsum; 6ZMX; -.
DR PDBsum; 6ZMY; -.
DR AlphaFoldDB; P81023; -.
DR SMR; P81023; -.
DR InParanoid; P81023; -.
DR EvolutionaryTrace; P81023; -.
DR Proteomes; UP000001645; Unplaced.
DR GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR CDD; cd08927; Hb-alpha-like; 1.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002338; Hemoglobin_a-typ.
DR InterPro; IPR002339; Hemoglobin_pi.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00612; ALPHAHAEM.
DR PRINTS; PR00815; PIHAEM.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Heme; Iron; Metal-binding;
KW Oxygen transport; Reference proteome; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:7576241"
FT CHAIN 2..142
FT /note="Hemoglobin subunit alpha-A"
FT /id="PRO_0000052689"
FT BINDING 59
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT BINDING 88
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
FT HELIX 5..18
FT /evidence="ECO:0007829|PDB:6ZMX"
FT HELIX 19..21
FT /evidence="ECO:0007829|PDB:2QMB"
FT HELIX 22..36
FT /evidence="ECO:0007829|PDB:6ZMX"
FT HELIX 38..43
FT /evidence="ECO:0007829|PDB:6ZMX"
FT HELIX 54..72
FT /evidence="ECO:0007829|PDB:6ZMX"
FT TURN 73..75
FT /evidence="ECO:0007829|PDB:6ZMX"
FT HELIX 77..89
FT /evidence="ECO:0007829|PDB:6ZMX"
FT HELIX 97..113
FT /evidence="ECO:0007829|PDB:6ZMX"
FT TURN 115..117
FT /evidence="ECO:0007829|PDB:6ZMX"
FT HELIX 120..137
FT /evidence="ECO:0007829|PDB:6ZMX"
SQ SEQUENCE 142 AA; 15441 MW; BB2634B9B6300407 CRC64;
MVLSAADKNN VKGIFTKIAG HAEEYGAETL ERMFITYPPT KTYFPHFDLS HGSAQIKGHG
KKVVAALIEA ANHIDDIAGT LSKLSDLHAH KLRVDPVNFK LLGQCFLVVV AIHHPAALTP
EVHASLDKFL CAVGTVLTAK YR
