ID   AN32A_DROPS             Reviewed;         263 AA.
AC   Q28XE2;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Acidic leucine-rich nuclear phosphoprotein 32 family member A;
GN   Name=Anp32a; Synonyms=Mapmodulin; ORFNames=GA19125;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
RN   [2]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=15895553; DOI=10.1080/14734220410019020;
RA   Matilla A., Radrizzani M.;
RT   "The Anp32 family of proteins containing leucine-rich repeats.";
RL   Cerebellum 4:7-18(2005).
CC   -!- FUNCTION: Implicated in a number of cellular processes, including
CC       proliferation, differentiation, caspase-dependent and caspase-
CC       independent apoptosis, suppression of transformation (tumor
CC       suppressor), inhibition of protein phosphatase 2A, regulation of mRNA
CC       trafficking and stability, and inhibition of acetyltransferases as part
CC       of the INHAT (inhibitor of histone acetyltransferases) complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Shuttles between nucleus
CC       and cytoplasm. {ECO:0000250}.
CC   -!- PTM: Phosphorylated on serine residues. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ANP32 family. {ECO:0000305}.
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DR   EMBL; CM000071; EAL26374.2; -; Genomic_DNA.
DR   RefSeq; XP_001361795.2; XM_001361758.4.
DR   AlphaFoldDB; Q28XE2; -.
DR   SMR; Q28XE2; -.
DR   STRING; 46245.Q28XE2; -.
DR   EnsemblMetazoa; FBtr0277521; FBpp0275959; FBgn0079123.
DR   GeneID; 4805386; -.
DR   KEGG; dpo:Dpse_GA19125; -.
DR   HOGENOM; CLU_063314_1_0_1; -.
DR   InParanoid; Q28XE2; -.
DR   ChiTaRS; Mapmodulin; fly.
DR   Proteomes; UP000001819; Chromosome 3.
DR   Bgee; FBgn0079123; Expressed in female reproductive system and 2 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
DR   GO; GO:0006913; P:nucleocytoplasmic transport; ISS:UniProtKB.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR045081; AN32.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PANTHER; PTHR11375; PTHR11375; 1.
DR   PROSITE; PS51450; LRR; 5.
PE   3: Inferred from homology;
KW   Cytoplasm; Leucine-rich repeat; Nucleus; Phosphoprotein;
KW   Reference proteome; Repeat.
FT   CHAIN           1..263
FT                   /note="Acidic leucine-rich nuclear phosphoprotein 32 family
FT                   member A"
FT                   /id="PRO_0000240189"
FT   REPEAT          16..37
FT                   /note="LRR 1"
FT   REPEAT          39..60
FT                   /note="LRR 2"
FT   REPEAT          61..83
FT                   /note="LRR 3"
FT   REPEAT          84..105
FT                   /note="LRR 4"
FT   DOMAIN          118..156
FT                   /note="LRRCT"
FT   REGION          144..263
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        146..231
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        241..263
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   263 AA;  29266 MW;  42E11A2413CBA2AE CRC64;
     MEKRIELERR ARKANQIQEL NLDNCRSTSI VGLTDEYTAL ESLSLINVGL TTLKGFPKLP
     NLKKLELSDN RISSGLNYLT TSPKLQYLNL SGNKIKDLET LKPLEEFKSL AVLDLFNNDA
     TQVDNYREKI FKMLPSLNFL DGFDCNDEEA QSEGDDDEEV NGNDSEEEVS GDDDEEDGDS
     DDSDEDGDNG EVSLSEVYND DLEEDNSDWE EGEGGGDDDE EDSDIDDADG EANESSASLN
     ASKKEPEKTD ESQARGKKRK HDG