ID   AN32A_XENLA             Reviewed;         244 AA.
AC   Q6PAF6;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Acidic leucine-rich nuclear phosphoprotein 32 family member A;
GN   Name=anp32a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=15895553; DOI=10.1080/14734220410019020;
RA   Matilla A., Radrizzani M.;
RT   "The Anp32 family of proteins containing leucine-rich repeats.";
RL   Cerebellum 4:7-18(2005).
CC   -!- FUNCTION: Implicated in a number of cellular processes, including
CC       proliferation, differentiation, caspase-dependent and caspase-
CC       independent apoptosis, suppression of transformation (tumor
CC       suppressor), inhibition of protein phosphatase 2A, regulation of mRNA
CC       trafficking and stability, and inhibition of acetyltransferases as part
CC       of the INHAT (inhibitor of histone acetyltransferases) complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Endoplasmic reticulum {ECO:0000250}.
CC   -!- PTM: Phosphorylated on serine residues. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ANP32 family. {ECO:0000305}.
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DR   EMBL; BC060336; AAH60336.1; -; mRNA.
DR   RefSeq; NP_001083156.1; NM_001089687.1.
DR   AlphaFoldDB; Q6PAF6; -.
DR   SMR; Q6PAF6; -.
DR   IntAct; Q6PAF6; 1.
DR   MaxQB; Q6PAF6; -.
DR   DNASU; 398775; -.
DR   GeneID; 398775; -.
DR   KEGG; xla:398775; -.
DR   CTD; 398775; -.
DR   Xenbase; XB-GENE-982555; anp32a.L.
DR   OMA; DKRSAFC; -.
DR   OrthoDB; 1622194at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 398775; Expressed in lung and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
DR   GO; GO:0006913; P:nucleocytoplasmic transport; ISS:UniProtKB.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR045081; AN32.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PANTHER; PTHR11375; PTHR11375; 1.
DR   PROSITE; PS51450; LRR; 4.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Endoplasmic reticulum; Leucine-rich repeat; Nucleus;
KW   Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..244
FT                   /note="Acidic leucine-rich nuclear phosphoprotein 32 family
FT                   member A"
FT                   /id="PRO_0000240186"
FT   REPEAT          18..41
FT                   /note="LRR 1"
FT   REPEAT          43..64
FT                   /note="LRR 2"
FT   REPEAT          65..87
FT                   /note="LRR 3"
FT   REPEAT          89..110
FT                   /note="LRR 4"
FT   DOMAIN          123..161
FT                   /note="LRRCT"
FT   REGION          148..244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        161..225
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   244 AA;  27772 MW;  7BFF5E9C2E66AB13 CRC64;
     MDMKKRIHLE LRNRTPADVK ELVLDNCRSK EGKIEGLTDE FEGLEFLSTI NVCLSSIANL
     PKLNKLKKLE LSDNNISGGL EVLAEKCPNL THLNLSGNRI KDLSTIEPLK KLEHLKSLDL
     FNCEVTNLND YRENLFKLLP QLTYLDGYDR DDKEAPDSDA EGYVEGLDDD EDDEDEDDYD
     EDVPPGEEGE DDDDEEEGEE EEVSGEEEED EDASREGEED EGDEEAEHGE KRKRDQDDEG
     EDDD