ID   HBA_PSIKR               Reviewed;         141 AA.
AC   P19831;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Hemoglobin subunit alpha;
DE   AltName: Full=Alpha-globin;
DE   AltName: Full=Hemoglobin alpha chain;
GN   Name=HBA;
OS   Psittacula krameri (Rose-ringed parakeet).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Psittacula.
OX   NCBI_TaxID=9228;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=3255379; DOI=10.1007/bf01024874;
RA   Islam A., Beg O.U., Persson B., Zaidi Z.H., Joernvall H.;
RT   "Primary structure of the hemoglobin alpha-chain of rose-ringed parakeet
RT   (Psittacula krameri).";
RL   J. Protein Chem. 7:561-569(1988).
CC   -!- FUNCTION: Involved in oxygen transport from the lung to the various
CC       peripheral tissues.
CC   -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC   -!- TISSUE SPECIFICITY: Red blood cells.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   PIR; A30332; A30332.
DR   PDB; 2ZFB; X-ray; 3.00 A; A=1-141.
DR   PDBsum; 2ZFB; -.
DR   AlphaFoldDB; P19831; -.
DR   SMR; P19831; -.
DR   EvolutionaryTrace; P19831; -.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd08927; Hb-alpha-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002338; Hemoglobin_a-typ.
DR   InterPro; IPR002339; Hemoglobin_pi.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00612; ALPHAHAEM.
DR   PRINTS; PR00815; PIHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Direct protein sequencing; Heme; Iron; Metal-binding;
KW   Oxygen transport; Transport.
FT   CHAIN           1..141
FT                   /note="Hemoglobin subunit alpha"
FT                   /id="PRO_0000052742"
FT   BINDING         58
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT   BINDING         87
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT   HELIX           4..16
FT                   /evidence="ECO:0007829|PDB:2ZFB"
FT   HELIX           18..20
FT                   /evidence="ECO:0007829|PDB:2ZFB"
FT   HELIX           21..35
FT                   /evidence="ECO:0007829|PDB:2ZFB"
FT   HELIX           37..41
FT                   /evidence="ECO:0007829|PDB:2ZFB"
FT   STRAND          44..46
FT                   /evidence="ECO:0007829|PDB:2ZFB"
FT   HELIX           53..71
FT                   /evidence="ECO:0007829|PDB:2ZFB"
FT   TURN            72..74
FT                   /evidence="ECO:0007829|PDB:2ZFB"
FT   HELIX           76..79
FT                   /evidence="ECO:0007829|PDB:2ZFB"
FT   TURN            80..82
FT                   /evidence="ECO:0007829|PDB:2ZFB"
FT   HELIX           83..88
FT                   /evidence="ECO:0007829|PDB:2ZFB"
FT   HELIX           96..112
FT                   /evidence="ECO:0007829|PDB:2ZFB"
FT   TURN            114..116
FT                   /evidence="ECO:0007829|PDB:2ZFB"
FT   HELIX           119..135
FT                   /evidence="ECO:0007829|PDB:2ZFB"
FT   HELIX           138..140
FT                   /evidence="ECO:0007829|PDB:2ZFB"
SQ   SEQUENCE   141 AA;  15126 MW;  FB0EC4BBF2F01AF4 CRC64;
     VLSGTDKTNV KSIFSKIGGQ ADDYGAEALE RMFVTYPQTK TYFPHFDVSP GSAQVKAHGK
     KVAGGLSEAA NHIDDIATSL SKLSDLHAQK LRVDPVNFKL LGQCFLVVVA IHNPSALTPE
     AHASLDKFLC AVGLVLTAKY R