ID   HBA_RHEAM               Reviewed;         141 AA.
AC   P01982;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Hemoglobin subunit alpha-A;
DE   AltName: Full=Alpha-A-globin;
DE   AltName: Full=Hemoglobin alpha-A chain;
GN   Name=HBAA;
OS   Rhea americana (Greater rhea) (Common rhea).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Palaeognathae; Rheiformes; Rheidae; Rhea.
OX   NCBI_TaxID=8797;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=6840701;
RA   Oberthur W., Braunitzer G., Baumann R., Wright P.G.;
RT   "Primary structures of the alpha and beta chains from the major hemoglobin
RT   component of the ostrich (Struthio camelus) and American rhea (Rhea
RT   americana) (Struthioformes). Aspects of respiratory physiology and
RT   taxonomy.";
RL   Hoppe-Seyler's Z. Physiol. Chem. 364:119-134(1983).
CC   -!- FUNCTION: Involved in oxygen transport from the lung to the various
CC       peripheral tissues.
CC   -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC   -!- TISSUE SPECIFICITY: Red blood cells.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   PIR; A02305; HAEH.
DR   AlphaFoldDB; P01982; -.
DR   SMR; P01982; -.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd08927; Hb-alpha-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002338; Hemoglobin_a-typ.
DR   InterPro; IPR002339; Hemoglobin_pi.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00612; ALPHAHAEM.
DR   PRINTS; PR00815; PIHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW   Transport.
FT   CHAIN           1..141
FT                   /note="Hemoglobin subunit alpha-A"
FT                   /id="PRO_0000052752"
FT   BINDING         58
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT   BINDING         87
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
SQ   SEQUENCE   141 AA;  15409 MW;  9DEDD577D589D333 CRC64;
     VLSGPDKTNV KNVFAKIGGH ADAYGAETLE RMFTTYPQTK TYFPHFDLHH GSAQIKTHGK
     KVVSALIDAA NNIDDIYGAL SKLSDLHAQK LRVDPVNFKL LGQCFLVVVA IHHPSLLTPE
     VHASLDKFLC AVGAVLTAKY R