ID   HBA_SALSA               Reviewed;         143 AA.
AC   P11251;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Hemoglobin subunit alpha;
DE   AltName: Full=Alpha-globin;
DE   AltName: Full=Hemoglobin alpha chain;
GN   Name=hba;
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Kidney;
RX   PubMed=2740221; DOI=10.1093/nar/17.11.4369;
RA   Wolff J.P., Gannon F.;
RT   "cDNA and deduced amino acid sequence of the Salmo salar (Atlantic salmon)
RT   adult hemoglobin alpha chain.";
RL   Nucleic Acids Res. 17:4369-4369(1989).
CC   -!- FUNCTION: Involved in oxygen transport from gills to the various
CC       peripheral tissues.
CC   -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC   -!- TISSUE SPECIFICITY: Red blood cells.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   EMBL; X14431; CAA32596.1; -; mRNA.
DR   PIR; S04589; S04589.
DR   RefSeq; NP_001117134.1; NM_001123662.1.
DR   AlphaFoldDB; P11251; -.
DR   SMR; P11251; -.
DR   GeneID; 100136572; -.
DR   KEGG; sasa:100136572; -.
DR   CTD; 15121; -.
DR   OrthoDB; 1398217at2759; -.
DR   Proteomes; UP000087266; Unplaced.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd08927; Hb-alpha-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002338; Hemoglobin_a-typ.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00612; ALPHAHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   2: Evidence at transcript level;
KW   Heme; Iron; Metal-binding; Oxygen transport; Reference proteome; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT   CHAIN           2..143
FT                   /note="Hemoglobin subunit alpha"
FT                   /id="PRO_0000052760"
FT   BINDING         60
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT   BINDING         89
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
SQ   SEQUENCE   143 AA;  15219 MW;  ED88BAD50FCBBA4C CRC64;
     MSLTARDKSV VNAFWGKIKG KADVVGAEAL GRMLTAYPQT KTYFSHWADL SPGSAPVKKH
     GGVIMGAIGN AVGLMDDLVG GMSGLSDLHA FKLRVDPGNF KILSHNILVT LAIHFPADFT
     PEVHIAVDKF LAALSAALAD KYR