HBA_XENTR
ID HBA_XENTR Reviewed; 142 AA.
AC P07428; Q5I0T1;
DT 01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Hemoglobin subunit alpha;
DE AltName: Full=Alpha-globin;
DE AltName: Full=Hemoglobin alpha chain;
GN Name=hba-A; Synonyms=hba;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3100812; DOI=10.1007/bf02115578;
RA Knoechel W., Korge E., Basner A., Meyerhof W.;
RT "Globin evolution in the genus Xenopus: comparative analysis of cDNAs
RT coding for adult globin polypeptides of Xenopus borealis and Xenopus
RT tropicalis.";
RL J. Mol. Evol. 23:211-223(1986).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3148743; DOI=10.1007/bf02143498;
RA Stalder J., Wirthmueller U., Beck J., Gruber A., Meyerhof W., Knoechel W.,
RA Weber R.;
RT "Primary structure and evolutionary relationship between the adult alpha-
RT globin genes and their 5'-flanking regions of Xenopus laevis and Xenopus
RT tropicalis.";
RL J. Mol. Evol. 28:64-71(1988).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Roche D.D., Cheng J.F., Harland R.M.;
RT "Characterization of alpha globin genes in Xenopus tropicalis.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in oxygen transport from the lung to the various
CC peripheral tissues.
CC -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC -!- TISSUE SPECIFICITY: Red blood cells.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
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DR EMBL; M32454; AAA49644.1; -; mRNA.
DR EMBL; X14260; CAA32473.1; -; Genomic_DNA.
DR EMBL; DQ224419; ABB04106.1; -; Genomic_DNA.
DR EMBL; BC088005; AAH88005.1; -; mRNA.
DR PIR; S02732; HAXLWA.
DR RefSeq; NP_988860.1; NM_203529.1.
DR AlphaFoldDB; P07428; -.
DR SMR; P07428; -.
DR PaxDb; P07428; -.
DR DNASU; 394454; -.
DR Ensembl; ENSXETT00000002494; ENSXETP00000002494; ENSXETG00000025664.
DR GeneID; 394454; -.
DR KEGG; xtr:394454; -.
DR CTD; 3039; -.
DR Xenbase; XB-GENE-478141; hba1.
DR eggNOG; KOG3378; Eukaryota.
DR HOGENOM; CLU_003827_10_2_1; -.
DR InParanoid; P07428; -.
DR OrthoDB; 1398217at2759; -.
DR PhylomeDB; P07428; -.
DR Proteomes; UP000008143; Chromosome 9.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000025664; Expressed in liver and 17 other tissues.
DR GO; GO:0031838; C:haptoglobin-hemoglobin complex; IBA:GO_Central.
DR GO; GO:0005833; C:hemoglobin complex; IBA:GO_Central.
DR GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043177; F:organic acid binding; IBA:GO_Central.
DR GO; GO:0019825; F:oxygen binding; IBA:GO_Central.
DR GO; GO:0005344; F:oxygen carrier activity; IBA:GO_Central.
DR GO; GO:0098869; P:cellular oxidant detoxification; IEA:GOC.
DR GO; GO:0042744; P:hydrogen peroxide catabolic process; IBA:GO_Central.
DR CDD; cd08927; Hb-alpha-like; 1.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002338; Hemoglobin_a-typ.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00612; ALPHAHAEM.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 2: Evidence at transcript level;
KW Heme; Iron; Metal-binding; Oxygen transport; Reference proteome; Transport.
FT INIT_MET 1
FT /note="Removed"
FT CHAIN 2..142
FT /note="Hemoglobin subunit alpha"
FT /id="PRO_0000052812"
FT BINDING 59
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT BINDING 88
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
SQ SEQUENCE 142 AA; 15887 MW; 28A69C015BC99200 CRC64;
MHLTADDKKH IKAIWPSVAA HGDKYGGEAL HRMFMCAPKT KTYFPDFDFS EHSKHILAHG
KKVSDALNEA CNHLDNIAGC LSKLSDLHAY DLRVDPGNFP LLAHQILVVV AIHFPKQFDP
ATHKALDKFL VSVSNVLTSK YR