ID   AN32B_XENLA             Reviewed;         239 AA.
AC   Q8AVC1;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Acidic leucine-rich nuclear phosphoprotein 32 family member B;
GN   Name=anp32b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=15895553; DOI=10.1080/14734220410019020;
RA   Matilla A., Radrizzani M.;
RT   "The Anp32 family of proteins containing leucine-rich repeats.";
RL   Cerebellum 4:7-18(2005).
CC   -!- FUNCTION: Multifunctional protein working as a cell cycle progression
CC       factor as well as a cell survival factor. Required for the progression
CC       from the G1 to the S phase. Anti-apoptotic protein which functions as a
CC       caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity.
CC       Exhibits histone chaperone properties, stimulating core histones to
CC       assemble into a nucleosome (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- DOMAIN: Histone binding is mediated by the concave surface of the LRR
CC       region. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ANP32 family. {ECO:0000305}.
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DR   EMBL; BC042250; AAH42250.1; -; mRNA.
DR   RefSeq; NP_001079433.1; NM_001085964.1.
DR   AlphaFoldDB; Q8AVC1; -.
DR   SMR; Q8AVC1; -.
DR   BioGRID; 97363; 1.
DR   DNASU; 379120; -.
DR   GeneID; 379120; -.
DR   KEGG; xla:379120; -.
DR   CTD; 379120; -.
DR   Xenbase; XB-GENE-17337640; anp32c.L.
DR   OrthoDB; 1392829at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 379120; Expressed in gastrula and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR045081; AN32.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PANTHER; PTHR11375; PTHR11375; 1.
DR   PROSITE; PS51450; LRR; 4.
PE   2: Evidence at transcript level;
KW   Chaperone; Leucine-rich repeat; Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..239
FT                   /note="Acidic leucine-rich nuclear phosphoprotein 32 family
FT                   member B"
FT                   /id="PRO_0000240190"
FT   REPEAT          16..40
FT                   /note="LRR 1"
FT   REPEAT          43..64
FT                   /note="LRR 2"
FT   REPEAT          65..87
FT                   /note="LRR 3"
FT   REPEAT          89..110
FT                   /note="LRR 4"
FT   DOMAIN          123..165
FT                   /note="LRRCT"
FT   REGION          149..239
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        150..213
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   239 AA;  27416 MW;  7D2BA8FD6CB8ED30 CRC64;
     MDMKKRLMLE LRNRKAADAK ELVLDNCRSD DGKIIGLTSE FESLEFLSMI NVNLLSVANL
     PKLPKLKKLE LSDNRISGGL EVLAERTPNL THLNLSGNKI KEINTLEPLK KLPHLMSLDL
     FNCEVTMLNN YRESVFELLP KLTFLDGFDA DDQEAPDSDP EAEDLEENGE DGEEDEEDDE
     EEEEFEDELD DEDEDEEGEE EEDGEEEDED DEDVPQGEKR KRDLSDEGEE EEEDDEDDE