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HBB1_PANPS
ID   HBB1_PANPS              Reviewed;         147 AA.
AC   P68051; P10884;
DT   25-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Hemoglobin subunit beta-1;
DE   AltName: Full=Beta-1-globin;
DE   AltName: Full=Hemoglobin beta-1 chain;
GN   Name=HBB1;
OS   Panthera pardus saxicolor (Northern persian leopard).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Pantherinae;
OC   Panthera.
OX   NCBI_TaxID=9693;
RN   [1]
RP   PROTEIN SEQUENCE OF 2-147, AND ACETYLATION AT SER-2.
RA   Ahmed A., Jahan M., Braunitzer G., Goeltenboth R.;
RT   "Carnivora: the primary structure of the major and minor hemoglobin
RT   components of adult north Persian leopard (Panthera pardus sexicolor).";
RL   Z. Naturforsch. C 43:1341-1346(1988).
CC   -!- FUNCTION: Involved in oxygen transport from the lung to the various
CC       peripheral tissues.
CC   -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC   -!- TISSUE SPECIFICITY: Red blood cells.
CC   -!- MISCELLANEOUS: In the cat family (felidae), the oxygen affinity of
CC       hemoglobin depends little or not at all on the association with
CC       diphosphoglycerate (DPG).
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   PIR; S03928; HBPD1P.
DR   AlphaFoldDB; P68051; -.
DR   SMR; P68051; -.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd08925; Hb-beta-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002337; Hemoglobin_b.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00814; BETAHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Direct protein sequencing; Heme; Iron; Metal-binding;
KW   Methylation; Oxygen transport; Phosphoprotein; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|Ref.1"
FT   CHAIN           2..147
FT                   /note="Hemoglobin subunit beta-1"
FT                   /id="PRO_0000053058"
FT   BINDING         64
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT   BINDING         93
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000269|Ref.1"
FT   MOD_RES         18
FT                   /note="N6-succinyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P02088"
FT   MOD_RES         45
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02091"
FT   MOD_RES         51
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02091"
FT   MOD_RES         60
FT                   /note="N6-succinyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P02089"
FT   MOD_RES         105
FT                   /note="Asymmetric dimethylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:P02089"
SQ   SEQUENCE   147 AA;  16117 MW;  E8FC401595CCBD37 CRC64;
     MSFLSAEEKG LVNGLWSKVN VDEVGGEALG RLLVVYPWTQ RFFQSFGDLS SADAIMSNAK
     VKAHGKKVLN SFSDGLKNID DLKGAFAKLS ELHCDKLHVD PENFRLLGNV LVCVLAHHFG
     HEFNPQVQAA FQKVVAGVAS ALAHRYH
 
 
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