ID   AN32B_XENTR             Reviewed;         242 AA.
AC   Q6P1U7;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Acidic leucine-rich nuclear phosphoprotein 32 family member B;
GN   Name=anp32b; ORFNames=TGas062k23.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=15895553; DOI=10.1080/14734220410019020;
RA   Matilla A., Radrizzani M.;
RT   "The Anp32 family of proteins containing leucine-rich repeats.";
RL   Cerebellum 4:7-18(2005).
CC   -!- FUNCTION: Multifunctional protein working as a cell cycle progression
CC       factor as well as a cell survival factor. Required for the progression
CC       from the G1 to the S phase. Anti-apoptotic protein which functions as a
CC       caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity.
CC       Exhibits histone chaperone properties, stimulating core histones to
CC       assemble into a nucleosome (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- DOMAIN: Histone binding is mediated by the concave surface of the LRR
CC       region. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ANP32 family. {ECO:0000305}.
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DR   EMBL; CR855787; CAJ81595.1; -; mRNA.
DR   EMBL; BC064864; AAH64864.1; -; mRNA.
DR   RefSeq; NP_989404.1; NM_204073.1.
DR   AlphaFoldDB; Q6P1U7; -.
DR   SMR; Q6P1U7; -.
DR   PaxDb; Q6P1U7; -.
DR   PRIDE; Q6P1U7; -.
DR   DNASU; 395041; -.
DR   Ensembl; ENSXETT00000021012; ENSXETP00000021012; ENSXETG00000009516.
DR   GeneID; 395041; -.
DR   KEGG; xtr:395041; -.
DR   CTD; 23520; -.
DR   Xenbase; XB-GENE-991758; anp32c.
DR   eggNOG; KOG2739; Eukaryota.
DR   HOGENOM; CLU_063314_1_1_1; -.
DR   InParanoid; Q6P1U7; -.
DR   OMA; VNDCEAS; -.
DR   OrthoDB; 1622194at2759; -.
DR   PhylomeDB; Q6P1U7; -.
DR   TreeFam; TF317206; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000009516; Expressed in gastrula and 15 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0042981; P:regulation of apoptotic process; IBA:GO_Central.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR045081; AN32.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR003603; U2A'_phosphoprotein32A_C.
DR   PANTHER; PTHR11375; PTHR11375; 1.
DR   SMART; SM00446; LRRcap; 1.
DR   PROSITE; PS51450; LRR; 4.
PE   2: Evidence at transcript level;
KW   Chaperone; Leucine-rich repeat; Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..242
FT                   /note="Acidic leucine-rich nuclear phosphoprotein 32 family
FT                   member B"
FT                   /id="PRO_0000280064"
FT   REPEAT          18..38
FT                   /note="LRR 1"
FT   REPEAT          43..64
FT                   /note="LRR 2"
FT   REPEAT          65..87
FT                   /note="LRR 3"
FT   REPEAT          89..110
FT                   /note="LRR 4"
FT   DOMAIN          123..165
FT                   /note="LRRCT"
FT   REGION          148..242
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        150..215
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   242 AA;  27772 MW;  E7940300375F31D6 CRC64;
     MEMKKRLMLE LRNRKAADVK ELVLDNCRSD DGKIIGLTSE FENLEFLSMI NVNLLSVANL
     PKLPKLKKLE LSDNRISGGL EVLAERTPNL THLNLSGNKI KEINTLEPLK KLPHLMSLDL
     FNCEVTMLNN YRESVFELLP QLTFLDGFDA DDQEAPDSDP EAEDLEENGE DGEDDEEDEE
     EFEDELDDEE DDEEGEDEEG EEEEEGDEED EDDEDVPQGE KRKRDLEDDG DEEDDDDEED
     DE