HBB1_SAAHA
ID HBB1_SAAHA Reviewed; 146 AA.
AC P18991;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Hemoglobin subunit beta-1;
DE AltName: Full=Beta-1-globin;
DE AltName: Full=Hemoglobin beta-1 chain;
DE Flags: Fragments;
OS Saara hardwickii (Indian spiny-tailed lizard) (Uromastyx hardwickii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Acrodonta; Agamidae; Uromastycinae; Saara.
OX NCBI_TaxID=40250;
RN [1]
RP PROTEIN SEQUENCE.
RX PubMed=6628672; DOI=10.1016/0014-5793(83)80774-1;
RA Naqvi S., Zaidi Z.H., von Bahr-Lindstroem H., Carlquist M., Joernvall H.;
RT "Characterization of hemoglobin from the lizard Uromastix hardwickii.";
RL FEBS Lett. 162:290-295(1983).
CC -!- FUNCTION: Involved in oxygen transport from the lung to the various
CC peripheral tissues.
CC -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC -!- TISSUE SPECIFICITY: Red blood cells.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
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DR PIR; A05304; A05304.
DR GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002337; Hemoglobin_b.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00814; BETAHAEM.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW Transport.
FT CHAIN 1..146
FT /note="Hemoglobin subunit beta-1"
FT /id="PRO_0000053145"
FT BINDING 92
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
SQ SEQUENCE 146 AA; 16164 MW; 3FFEE0435F245EE9 CRC64;
VHWTAEEKAL INAYWGKVDV GSVGGETLAN LLVVYPWTQR FFEDFGNLST PSAILNNPKX
XXXXXXVITS FGDALKNLDN VXXXXXKLSE YHCNKLHVDP VNFRLLGDVL ITLSAANFGK
XXXXXXXXXX XXLVGVVAHA LARRYH