HBB1_TRICR
ID HBB1_TRICR Reviewed; 145 AA.
AC P10785;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1989, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Hemoglobin subunit beta-1;
DE AltName: Full=Beta-1-globin;
DE AltName: Full=Hemoglobin beta-1 chain;
DE AltName: Full=Hemoglobin beta-major chain;
GN Name=HBB1;
OS Triturus cristatus (Great crested newt) (Warty newt).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Caudata; Salamandroidea; Salamandridae; Pleurodelinae; Triturus.
OX NCBI_TaxID=8323;
RN [1]
RP PROTEIN SEQUENCE.
RX PubMed=3242554; DOI=10.1515/bchm3.1988.369.2.1343;
RA Kleinschmidt T., Sgouros J.G., Braunitzer G.;
RT "The first sequenced normal hemoglobin lacking histidine in position 146 of
RT the beta-chains. The primary structures of the major and minor hemoglobin
RT components of the great crested newt (Triturus cristatus, Urodela,
RT Amphibia).";
RL Biol. Chem. Hoppe-Seyler 369:1343-1360(1988).
CC -!- FUNCTION: Involved in oxygen transport from the lung to the various
CC peripheral tissues.
CC -!- SUBUNIT: Major hemoglobin is a tetramer of two alpha-1 chains and two
CC beta-1 chains.
CC -!- TISSUE SPECIFICITY: Red blood cells.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
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DR PIR; S02025; S02025.
DR AlphaFoldDB; P10785; -.
DR SMR; P10785; -.
DR GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR CDD; cd08925; Hb-beta-like; 1.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002337; Hemoglobin_b.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00814; BETAHAEM.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW Transport.
FT CHAIN 1..145
FT /note="Hemoglobin subunit beta-1"
FT /id="PRO_0000053138"
FT BINDING 62
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT BINDING 91
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
SQ SEQUENCE 145 AA; 16003 MW; BEF06F441B42BA80 CRC64;
TFTNDESQHI HDVCGKIPVD QVGAEALGRL ILVNPWTRRY FKSFGDLSSA EAIQHNPKVA
SHGAKVMHSI AEAVKHLDDL KAYYADLSTI HCKKLYVDPA NFKLFGGIVS IVTGMHLGTD
YTAQKQAAFE KFLHHVEAAL ATGYH