AN32C_HUMAN
ID AN32C_HUMAN Reviewed; 234 AA.
AC O43423; Q4W5F9;
DT 06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 25-MAY-2022, entry version 147.
DE RecName: Full=Acidic leucine-rich nuclear phosphoprotein 32 family member C;
DE AltName: Full=Phosphoprotein 32-related protein 1;
DE AltName: Full=Tumorigenic protein pp32r1;
GN Name=ANP32C; Synonyms=PP32R1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RX PubMed=10086381; DOI=10.1038/6488;
RA Kadkol S.S., Brody J.R., Pevsner J., Bai J., Pasternack G.R.;
RT "Modulation of oncogenic potential by alternative gene use in human
RT prostate cancer.";
RL Nat. Med. 5:275-279(1999).
RN [2]
RP ERRATUM OF PUBMED:10086381.
RX PubMed=10471270; DOI=10.1038/12530;
RA Kadkol S.S., Brody J.R., Pevsner J., Bai J., Pasternack G.R.;
RL Nat. Med. 5:1087-1087(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP VARIANTS VAL-23; LYS-71 AND HIS-140, AND TISSUE SPECIFICITY.
RX PubMed=15146458; DOI=10.1002/humu.20030;
RA Kochevar G.J., Brody J.R., Kadkol S.S., Murphy K.M., Pasternack G.R.;
RT "Identification of a functional mutation in pp32r1 (ANP32C).";
RL Hum. Mutat. 23:546-551(2004).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15895553; DOI=10.1080/14734220410019020;
RA Matilla A., Radrizzani M.;
RT "The Anp32 family of proteins containing leucine-rich repeats.";
RL Cerebellum 4:7-18(2005).
CC -!- TISSUE SPECIFICITY: Expressed in activated stem cells, such as
CC mobilized CD34+ cells and cord blood CD34+ cells, but not in resting
CC bone marrow CD34+ cells. Expressed in a variety of neoplastic cell
CC lines, mainly in prostatic adenocarcinoma cell lines. Not expressed in
CC normal prostatic tissue. {ECO:0000269|PubMed:10086381,
CC ECO:0000269|PubMed:15146458}.
CC -!- SIMILARITY: Belongs to the ANP32 family. {ECO:0000305}.
CC -!- CAUTION: The His-140 polymorphism is uncertain. It has been found in
CC prostatic cell line without corresponding normal tissue sample. Cells
CC transfected with this variant expressed at least twice as much proteins
CC than native cells. {ECO:0000305}.
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DR EMBL; AF008216; AAD12746.1; -; Genomic_DNA.
DR EMBL; AC105250; AAY40978.1; -; Genomic_DNA.
DR EMBL; CH471056; EAX04832.1; -; Genomic_DNA.
DR RefSeq; NP_036535.1; NM_012403.1.
DR AlphaFoldDB; O43423; -.
DR SMR; O43423; -.
DR BioGRID; 117067; 7.
DR IntAct; O43423; 3.
DR MINT; O43423; -.
DR iPTMnet; O43423; -.
DR PhosphoSitePlus; O43423; -.
DR BioMuta; HGNC:16675; -.
DR jPOST; O43423; -.
DR MassIVE; O43423; -.
DR MaxQB; O43423; -.
DR PeptideAtlas; O43423; -.
DR PRIDE; O43423; -.
DR DNASU; 23520; -.
DR GeneID; 23520; -.
DR CTD; 23520; -.
DR DisGeNET; 23520; -.
DR GeneCards; ANP32C; -.
DR HGNC; HGNC:16675; ANP32C.
DR MIM; 606877; gene.
DR neXtProt; NX_O43423; -.
DR PharmGKB; PA24813; -.
DR InParanoid; O43423; -.
DR OrthoDB; 1622194at2759; -.
DR PhylomeDB; O43423; -.
DR PathwayCommons; O43423; -.
DR SignaLink; O43423; -.
DR BioGRID-ORCS; 23520; 17 hits in 139 CRISPR screens.
DR GeneWiki; ANP32C; -.
DR GenomeRNAi; 23520; -.
DR Pharos; O43423; Tdark.
DR PRO; PR:O43423; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; O43423; protein.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IBA:GO_Central.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0006913; P:nucleocytoplasmic transport; IBA:GO_Central.
DR GO; GO:0042981; P:regulation of apoptotic process; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR045081; AN32.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR11375; PTHR11375; 1.
DR PROSITE; PS51450; LRR; 3.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..234
FT /note="Acidic leucine-rich nuclear phosphoprotein 32 family
FT member C"
FT /id="PRO_0000137597"
FT REPEAT 44..63
FT /note="LRR 1"
FT REPEAT 64..84
FT /note="LRR 2"
FT REPEAT 85..107
FT /note="LRR 3"
FT REPEAT 111..134
FT /note="LRR 4"
FT REGION 161..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..225
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 23
FT /note="A -> V (in dbSNP:rs2288674)"
FT /evidence="ECO:0000269|PubMed:15146458"
FT /id="VAR_026702"
FT VARIANT 71
FT /note="R -> K (in dbSNP:rs2288675)"
FT /evidence="ECO:0000269|PubMed:15146458"
FT /id="VAR_020419"
FT VARIANT 105
FT /note="L -> P (in dbSNP:rs17008716)"
FT /id="VAR_048314"
FT VARIANT 140
FT /note="Y -> H"
FT /evidence="ECO:0000269|PubMed:15146458"
FT /id="VAR_026703"
FT VARIANT 204
FT /note="E -> G (in dbSNP:rs2288676)"
FT /id="VAR_020420"
SQ SEQUENCE 234 AA; 26762 MW; 2515D9678EACC5C2 CRC64;
MEMGRRIHSE LRNRAPSDVK ELALDNSRSN EGKLEALTDE FEELEFLSKI NGGLTSISDL
PKLKLRKLEL RVSGGLEVLA EKCPNLTHLY LSGNKIKDLS TIEPLKQLEN LKSLDLFNCE
VTNLNDYGEN VFKLLLQLTY LDSCYWDHKE APYSDIEDHV EGLDDEEEGE HEEEYDEDAQ
VVEDEEGEEE EEEGEEEDVS GGDEEDEEGY NDGEVDGEED EEELGEEERG QKRK
