位置:首页 > 蛋白库 > HBB2_AMBCR
HBB2_AMBCR
ID   HBB2_AMBCR              Reviewed;         146 AA.
AC   P86391;
DT   15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT   15-JUN-2010, sequence version 1.
DT   03-AUG-2022, entry version 26.
DE   RecName: Full=Hemoglobin subunit beta-2 {ECO:0000250|UniProtKB:P22743};
DE   AltName: Full=Beta-2-globin {ECO:0000250|UniProtKB:P22743};
DE   AltName: Full=Hemoglobin beta-2 chain {ECO:0000250|UniProtKB:P22743};
DE   AltName: Full=Hemoglobin beta-II chain {ECO:0000250|UniProtKB:P22743, ECO:0000303|PubMed:20047955};
GN   Name=HBB2 {ECO:0000250|UniProtKB:P22743};
OS   Amblyrhynchus cristatus (Galapagos marine iguana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Iguania; Iguanidae; Iguaninae; Amblyrhynchus.
OX   NCBI_TaxID=51208;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE.
RC   TISSUE=Blood {ECO:0000269|PubMed:20047955};
RX   PubMed=20047955; DOI=10.1093/molbev/msp325;
RA   Hoffmann F.G., Storz J.F., Gorr T.A., Opazo J.C.;
RT   "Lineage-specific patterns of functional diversification in the alpha- and
RT   beta-globin gene families of tetrapod vertebrates.";
RL   Mol. Biol. Evol. 27:1126-1138(2010).
CC   -!- FUNCTION: Involved in oxygen transport from the lung to the various
CC       peripheral tissues. {ECO:0000305}.
CC   -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC       {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Red blood cells. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P86391; -.
DR   SMR; P86391; -.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd08925; Hb-beta-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002337; Hemoglobin_b.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00814; BETAHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW   Transport.
FT   CHAIN           1..146
FT                   /note="Hemoglobin subunit beta-2"
FT                   /id="PRO_0000394466"
FT   BINDING         63
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT                   /evidence="ECO:0000305"
FT   BINDING         92
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   146 AA;  16188 MW;  39ED05653BA01939 CRC64;
     VHWTAEEKQL ITCLWGKVDV ATIGGESLAG MFVMYPWTQR LFSEFGNLSS PTAICGNPKV
     KAHGKKVLTA FGDAIRNLDN IKDTFAKLSE LHCDKLHVDP ENFKLLGKVL LIVLAGHYGK
     DFTPACHAAY QKLVNVVAHA LARRYH
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024