HBB2_AMBCR
ID HBB2_AMBCR Reviewed; 146 AA.
AC P86391;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 15-JUN-2010, sequence version 1.
DT 03-AUG-2022, entry version 26.
DE RecName: Full=Hemoglobin subunit beta-2 {ECO:0000250|UniProtKB:P22743};
DE AltName: Full=Beta-2-globin {ECO:0000250|UniProtKB:P22743};
DE AltName: Full=Hemoglobin beta-2 chain {ECO:0000250|UniProtKB:P22743};
DE AltName: Full=Hemoglobin beta-II chain {ECO:0000250|UniProtKB:P22743, ECO:0000303|PubMed:20047955};
GN Name=HBB2 {ECO:0000250|UniProtKB:P22743};
OS Amblyrhynchus cristatus (Galapagos marine iguana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Iguanidae; Iguaninae; Amblyrhynchus.
OX NCBI_TaxID=51208;
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE.
RC TISSUE=Blood {ECO:0000269|PubMed:20047955};
RX PubMed=20047955; DOI=10.1093/molbev/msp325;
RA Hoffmann F.G., Storz J.F., Gorr T.A., Opazo J.C.;
RT "Lineage-specific patterns of functional diversification in the alpha- and
RT beta-globin gene families of tetrapod vertebrates.";
RL Mol. Biol. Evol. 27:1126-1138(2010).
CC -!- FUNCTION: Involved in oxygen transport from the lung to the various
CC peripheral tissues. {ECO:0000305}.
CC -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Red blood cells. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
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DR AlphaFoldDB; P86391; -.
DR SMR; P86391; -.
DR GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR CDD; cd08925; Hb-beta-like; 1.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002337; Hemoglobin_b.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00814; BETAHAEM.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW Transport.
FT CHAIN 1..146
FT /note="Hemoglobin subunit beta-2"
FT /id="PRO_0000394466"
FT BINDING 63
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT /evidence="ECO:0000305"
FT BINDING 92
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
FT /evidence="ECO:0000305"
SQ SEQUENCE 146 AA; 16188 MW; 39ED05653BA01939 CRC64;
VHWTAEEKQL ITCLWGKVDV ATIGGESLAG MFVMYPWTQR LFSEFGNLSS PTAICGNPKV
KAHGKKVLTA FGDAIRNLDN IKDTFAKLSE LHCDKLHVDP ENFKLLGKVL LIVLAGHYGK
DFTPACHAAY QKLVNVVAHA LARRYH