ID   AN32D_HUMAN             Reviewed;         131 AA.
AC   O95626; Q6NTC4;
DT   06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 2.
DT   03-AUG-2022, entry version 149.
DE   RecName: Full=Acidic leucine-rich nuclear phosphoprotein 32 family member D;
DE   AltName: Full=Phosphoprotein 32-related protein 2;
DE   AltName: Full=Tumorigenic protein pp32r2;
GN   Name=ANP32D; Synonyms=PP32R2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Placenta;
RX   PubMed=10086381; DOI=10.1038/6488;
RA   Kadkol S.S., Brody J.R., Pevsner J., Bai J., Pasternack G.R.;
RT   "Modulation of oncogenic potential by alternative gene use in human
RT   prostate cancer.";
RL   Nat. Med. 5:275-279(1999).
RN   [2]
RP   ERRATUM OF PUBMED:10086381.
RX   PubMed=10471270; DOI=10.1038/12530;
RA   Kadkol S.S., Brody J.R., Pevsner J., Bai J., Pasternack G.R.;
RL   Nat. Med. 5:1087-1087(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=15895553; DOI=10.1080/14734220410019020;
RA   Matilla A., Radrizzani M.;
RT   "The Anp32 family of proteins containing leucine-rich repeats.";
RL   Cerebellum 4:7-18(2005).
CC   -!- SIMILARITY: Belongs to the ANP32 family. {ECO:0000305}.
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DR   EMBL; U71084; AAD13667.1; -; Genomic_DNA.
DR   EMBL; BC069122; AAH69122.1; -; mRNA.
DR   CCDS; CCDS31788.1; -.
DR   RefSeq; NP_036536.2; NM_012404.2.
DR   AlphaFoldDB; O95626; -.
DR   SMR; O95626; -.
DR   STRING; 9606.ENSP00000266594; -.
DR   iPTMnet; O95626; -.
DR   PhosphoSitePlus; O95626; -.
DR   BioMuta; ANP32D; -.
DR   jPOST; O95626; -.
DR   MassIVE; O95626; -.
DR   MaxQB; O95626; -.
DR   PaxDb; O95626; -.
DR   PeptideAtlas; O95626; -.
DR   PRIDE; O95626; -.
DR   ProteomicsDB; 50957; -.
DR   Antibodypedia; 74725; 61 antibodies from 14 providers.
DR   DNASU; 23519; -.
DR   Ensembl; ENST00000266594.4; ENSP00000266594.2; ENSG00000139223.4.
DR   GeneID; 23519; -.
DR   KEGG; hsa:23519; -.
DR   MANE-Select; ENST00000266594.4; ENSP00000266594.2; NM_012404.3; NP_036536.2.
DR   UCSC; uc010slt.3; human.
DR   CTD; 23519; -.
DR   DisGeNET; 23519; -.
DR   GeneCards; ANP32D; -.
DR   HGNC; HGNC:16676; ANP32D.
DR   HPA; ENSG00000139223; Not detected.
DR   MIM; 606878; gene.
DR   neXtProt; NX_O95626; -.
DR   OpenTargets; ENSG00000139223; -.
DR   PharmGKB; PA24814; -.
DR   VEuPathDB; HostDB:ENSG00000139223; -.
DR   eggNOG; KOG2739; Eukaryota.
DR   GeneTree; ENSGT00950000182907; -.
DR   HOGENOM; CLU_063314_3_1_1; -.
DR   InParanoid; O95626; -.
DR   OMA; CRSTNIA; -.
DR   OrthoDB; 1468912at2759; -.
DR   PhylomeDB; O95626; -.
DR   TreeFam; TF317206; -.
DR   PathwayCommons; O95626; -.
DR   SignaLink; O95626; -.
DR   BioGRID-ORCS; 23519; 7 hits in 997 CRISPR screens.
DR   GeneWiki; ANP32D; -.
DR   GenomeRNAi; 23519; -.
DR   Pharos; O95626; Tdark.
DR   PRO; PR:O95626; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; O95626; protein.
DR   Bgee; ENSG00000139223; Expressed in sural nerve and 11 other tissues.
DR   Genevisible; O95626; HS.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR045081; AN32.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PANTHER; PTHR11375; PTHR11375; 1.
DR   PROSITE; PS51450; LRR; 4.
PE   2: Evidence at transcript level;
KW   Leucine-rich repeat; Reference proteome; Repeat.
FT   CHAIN           1..131
FT                   /note="Acidic leucine-rich nuclear phosphoprotein 32 family
FT                   member D"
FT                   /id="PRO_0000137598"
FT   REPEAT          18..38
FT                   /note="LRR 1"
FT   REPEAT          43..64
FT                   /note="LRR 2"
FT   REPEAT          65..87
FT                   /note="LRR 3"
FT   REPEAT          89..110
FT                   /note="LRR 4"
FT   REPEAT          114..131
FT                   /note="LRR 5"
FT   VARIANT         46
FT                   /note="L -> F (in dbSNP:rs7956679)"
FT                   /id="VAR_027832"
FT   CONFLICT        38
FT                   /note="T -> A (in Ref. 1; AAD13667)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        55
FT                   /note="T -> S (in Ref. 1; AAD13667)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   131 AA;  14806 MW;  C2B2749F83496C53 CRC64;
     MEMGKWIHLE LRNRTPSDVK ELFLDNSQSN EGKLEGLTDE FEELELLNTI NIGLTSIANL
     PKLNKLKKLE LSSNRASVGL EVLAEKCPNL IHLNLSGNKI KDLSTIEPLK KLENLESLDL
     FTCEVTNLNN Y