ID   HBB2_TELPE              Reviewed;         145 AA.
AC   P83114;
DT   28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2003, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Hemoglobin subunit beta-2;
DE   AltName: Full=Beta-2-globin;
DE   AltName: Full=Hemoglobin beta-2 chain;
OS   Telmatobius peruvianus (Andean frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Ceratophryidae; Telmatobiinae;
OC   Telmatobius.
OX   NCBI_TaxID=170953 {ECO:0000305};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE.
RX   PubMed=12376398; DOI=10.1152/ajpregu.00292.2002;
RA   Weber R.E., Ostojic H., Fago A., Dewilde S., Van Hauwaert M.-L., Moens L.,
RA   Monge C.;
RT   "Novel mechanism for high-altitude adaptation in hemoglobin of the Andean
RT   frog Telmatobius peruvianus.";
RL   Am. J. Physiol. 283:R1052-R1060(2002).
CC   -!- TISSUE SPECIFICITY: Red blood cells.
CC   -!- SIMILARITY: Belongs to the globin family.
CC       {ECO:0000250|UniProtKB:P02070, ECO:0000255|PROSITE-ProRule:PRU00238}.
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DR   AlphaFoldDB; P83114; -.
DR   SMR; P83114; -.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd08925; Hb-beta-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002337; Hemoglobin_b.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00814; BETAHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW   Transport.
FT   CHAIN           1..145
FT                   /note="Hemoglobin subunit beta-2"
FT                   /id="PRO_0000053128"
FT   BINDING         63
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT   BINDING         91
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
SQ   SEQUENCE   145 AA;  16144 MW;  178E5498F7D4619B CRC64;
     VHLTDQEIKY INAIWSKVDY KQVGGEALAR LLIVYPWTQR YFSTFGNLAS ADAISHNSKV
     IAHGEKVLRS IGEALKHLDN LKGYAKLSQY HSEKLHVDPA NFVRFGGVVV IVLAHHFHEE
     FTPEVQAAFE KAFGGVADAV GKGYH