HBB2_XENLA
ID HBB2_XENLA Reviewed; 147 AA.
AC P02133; P06644; Q66KT5;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Hemoglobin subunit beta-2;
DE AltName: Full=Beta-2-globin;
DE Short=B2G;
DE AltName: Full=Hemoglobin beta-2 chain;
DE AltName: Full=Hemoglobin beta-minor chain;
DE AltName: Full=Larval beta-II-globin;
GN Name=hbb2;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2999708; DOI=10.1093/nar/13.21.7899;
RA Knoechel W., Meyerhof W., Stalder J., Weber R.;
RT "Comparative nucleotide sequence analysis of two types of larval beta-
RT globin mRNAs of Xenopus laevis.";
RL Nucleic Acids Res. 13:7899-7908(1985).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3020391; DOI=10.1007/bf00419736;
RA Meyerhof W., Koester M., Stalder J., Weber R., Knoechel W.;
RT "Sequence analysis of the larval beta II-globin gene of Xenopus laevis.";
RL Mol. Biol. Rep. 11:155-161(1986).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in oxygen transport from the lung to the various
CC peripheral tissues.
CC -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC -!- TISSUE SPECIFICITY: Red blood cells.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
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DR EMBL; X03142; CAA26914.1; -; mRNA.
DR EMBL; M21411; AAA49653.1; -; Genomic_DNA.
DR EMBL; BC078566; AAH78566.1; -; mRNA.
DR PIR; A54492; A54492.
DR RefSeq; NP_001081497.1; NM_001088028.2.
DR AlphaFoldDB; P02133; -.
DR SMR; P02133; -.
DR DNASU; 397871; -.
DR GeneID; 397871; -.
DR KEGG; xla:397871; -.
DR CTD; 397871; -.
DR Xenbase; XB-GENE-5808117; hbg2.L.
DR OMA; SADAIMH; -.
DR OrthoDB; 1370439at2759; -.
DR Proteomes; UP000186698; Chromosome 9_10L.
DR Bgee; 397871; Expressed in internal ear and 2 other tissues.
DR GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR CDD; cd08925; Hb-beta-like; 1.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002337; Hemoglobin_b.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00814; BETAHAEM.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 2: Evidence at transcript level;
KW Heme; Iron; Metal-binding; Oxygen transport; Reference proteome; Transport.
FT INIT_MET 1
FT /note="Removed"
FT CHAIN 2..147
FT /note="Hemoglobin subunit beta-2"
FT /id="PRO_0000053156"
FT BINDING 64
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT BINDING 93
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
SQ SEQUENCE 147 AA; 15972 MW; F2879E197A0ECAEA CRC64;
MVHWTAEEKA AITSVWQKVN VEHDGHDALG RLLIVYPWTQ RYFSNFGNLS NSAAVAGNAK
VQAHGKKVLS AVGNAISHID SVKSSLQQLS KIHATELFVD PENFKRFGGV LVIVLGAKLG
TAFTPKVQAA WEKFIAVLVD GLSQGYN
