HBB2_XENTR
ID HBB2_XENTR Reviewed; 147 AA.
AC P08423; Q28HN1;
DT 01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Hemoglobin subunit beta-2;
DE AltName: Full=Beta-2-globin;
DE AltName: Full=Hemoglobin beta-2 chain;
DE AltName: Full=Larval beta-globin;
GN Name=hbb2; ORFNames=TTpA004i19.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3697074; DOI=10.1093/nar/15.23.10062;
RA Knoechel W., Beck J., Meyerhof W.;
RT "Nucleotide sequence of the Xenopus tropicalis larval beta globin gene.";
RL Nucleic Acids Res. 15:10062-10062(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tadpole;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This is a larval (tadpole) beta-globin.
CC -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC -!- TISSUE SPECIFICITY: Red blood cells.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
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DR EMBL; Y00501; CAA68554.1; -; Genomic_DNA.
DR EMBL; CR760812; CAJ83218.1; -; mRNA.
DR PIR; S06308; HBXLLW.
DR RefSeq; NP_001016495.1; NM_001016495.2.
DR AlphaFoldDB; P08423; -.
DR SMR; P08423; -.
DR PaxDb; P08423; -.
DR GeneID; 549249; -.
DR KEGG; xtr:549249; -.
DR CTD; 3046; -.
DR Xenbase; XB-GENE-5722135; hbe1.
DR eggNOG; KOG3378; Eukaryota.
DR InParanoid; P08423; -.
DR OrthoDB; 1370439at2759; -.
DR Proteomes; UP000008143; Chromosome 9.
DR Proteomes; UP000790000; Unplaced.
DR GO; GO:0031838; C:haptoglobin-hemoglobin complex; IBA:GO_Central.
DR GO; GO:0005833; C:hemoglobin complex; IBA:GO_Central.
DR GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043177; F:organic acid binding; IBA:GO_Central.
DR GO; GO:0019825; F:oxygen binding; IBA:GO_Central.
DR GO; GO:0005344; F:oxygen carrier activity; IBA:GO_Central.
DR GO; GO:0098869; P:cellular oxidant detoxification; IEA:GOC.
DR GO; GO:0042744; P:hydrogen peroxide catabolic process; IBA:GO_Central.
DR CDD; cd08925; Hb-beta-like; 1.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002337; Hemoglobin_b.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00814; BETAHAEM.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 2: Evidence at transcript level;
KW Heme; Iron; Metal-binding; Oxygen transport; Reference proteome; Transport.
FT INIT_MET 1
FT /note="Removed"
FT CHAIN 2..147
FT /note="Hemoglobin subunit beta-2"
FT /id="PRO_0000053159"
FT BINDING 64
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT BINDING 93
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
SQ SEQUENCE 147 AA; 16000 MW; 2818208FD94D260E CRC64;
MVHWTAEEKA TIASVWGKVD IEQDGHDALS RLLVVYPWTQ RYFSSFGNLS NVSAVSGNVK
VKAHGNKVLS AVGSAIQHLD DVKSHLKGLS KSHAEDLHVD PENFKRLADV LVIVLAAKLG
SAFTPQVQAV WEKLNATLVA ALSHGYF
