ID   HBB3_MURHE              Reviewed;         147 AA.
AC   Q7LZC1;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Hemoglobin subunit beta-3;
DE   AltName: Full=Beta-3-globin;
DE   AltName: Full=Hemoglobin beta-3 chain;
DE   AltName: Full=Hemoglobin beta-III chain;
GN   Name=hbb3;
OS   Muraena helena (Mediterranean moray).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Anguilliformes; Muraenidae;
OC   Muraena.
OX   NCBI_TaxID=46662;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=8536685; DOI=10.1111/j.1432-1033.1995.431_b.x;
RA   Pellegrini M., Giardina B., Olianas A., Sanna M.T., Deiana A.M.,
RA   Salvadori S., di Prisco G., Tamburrini M., Corda M.;
RT   "Structure/function relationships in the hemoglobin components from moray
RT   (Muraena helena).";
RL   Eur. J. Biochem. 234:431-436(1995).
CC   -!- FUNCTION: Involved in oxygen transport from gills to the various
CC       peripheral tissues.
CC   -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC   -!- TISSUE SPECIFICITY: Red blood cells.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   PIR; S67982; S67982.
DR   AlphaFoldDB; Q7LZC1; -.
DR   SMR; Q7LZC1; -.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd08925; Hb-beta-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002337; Hemoglobin_b.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00814; BETAHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW   Transport.
FT   CHAIN           1..147
FT                   /note="Hemoglobin subunit beta-3"
FT                   /id="PRO_0000053027"
FT   BINDING         63
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT   BINDING         92
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
SQ   SEQUENCE   147 AA;  16577 MW;  F92C9355E155C666 CRC64;
     VEWTDAERTA ILTLWKKINI DEIGPCAMRR LLIVSPWTQR HFSTFGNIST NAAIMDNDLV
     AKHGSTVMGG LDRAIKNMDD IKGAYRELSK KHSDQLHVDP DNFRLLAECI TLCVAGKFGP
     KEFTADVHEA WYKFLAAVTS ALSRQYH