HBB4_ONCMY
ID HBB4_ONCMY Reviewed; 148 AA.
AC P02141; Q91199;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Hemoglobin subunit beta-4;
DE AltName: Full=Beta-4-globin;
DE AltName: Full=Hemoglobin beta-4 chain;
DE AltName: Full=Hemoglobin beta-IV chain;
GN Name=hbb4;
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Yoshizaki G., Kang J.-H., Sakuma K., Aoki T., Takashima F.;
RT "Cloning and sequencing of rainbow trout beta-globin cDNA.";
RL Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP PROTEIN SEQUENCE OF 2-148.
RA Petruzzelli R., Barra D., Goffredo B.M., Bossa F., Coletta M., Brunori M.;
RT "Amino-acid sequence of beta-chain of hemoglobin IV from trout (Salmo
RT irideus).";
RL Biochim. Biophys. Acta 789:69-73(1984).
RN [3]
RP PROTEIN SEQUENCE OF 2-42 AND 46-86.
RX PubMed=1269767; DOI=10.1016/0014-5793(76)80253-0;
RA Bossa F., Barra D., Coletta M., Martini F., Liverzani A., Petruzzelli R.,
RA Bonaventura J., Brunori M.;
RT "Primary structure of hemoglobins from trout (Salmo irideus). Partial
RT determination of amino acid sequence of HB trout IV.";
RL FEBS Lett. 64:76-80(1976).
CC -!- FUNCTION: Involved in oxygen transport from gills to the various
CC peripheral tissues.
CC -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC -!- TISSUE SPECIFICITY: Red blood cells.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
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DR EMBL; D82926; BAA11632.1; -; mRNA.
DR PIR; A02461; HBTR4.
DR RefSeq; NP_001118017.1; NM_001124545.1.
DR PDB; 2R1H; X-ray; 1.90 A; B/D=2-148.
DR PDB; 3BOM; X-ray; 1.35 A; B/D=2-148.
DR PDBsum; 2R1H; -.
DR PDBsum; 3BOM; -.
DR AlphaFoldDB; P02141; -.
DR SMR; P02141; -.
DR GeneID; 100136291; -.
DR KEGG; omy:100136291; -.
DR OrthoDB; 1370439at2759; -.
DR EvolutionaryTrace; P02141; -.
DR GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR CDD; cd08925; Hb-beta-like; 1.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002337; Hemoglobin_b.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00814; BETAHAEM.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Heme; Iron; Metal-binding;
KW Oxygen transport; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:1269767, ECO:0000269|Ref.2"
FT CHAIN 2..148
FT /note="Hemoglobin subunit beta-4"
FT /id="PRO_0000053101"
FT BINDING 64
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT BINDING 93
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
FT CONFLICT 7
FT /note="P -> A (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 78..81
FT /note="NLDD -> DLBB (in Ref. 3; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 87..88
FT /note="TA -> AT (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
FT HELIX 6..18
FT /evidence="ECO:0007829|PDB:3BOM"
FT HELIX 21..35
FT /evidence="ECO:0007829|PDB:3BOM"
FT HELIX 37..42
FT /evidence="ECO:0007829|PDB:3BOM"
FT HELIX 44..46
FT /evidence="ECO:0007829|PDB:3BOM"
FT HELIX 52..56
FT /evidence="ECO:0007829|PDB:3BOM"
FT HELIX 59..77
FT /evidence="ECO:0007829|PDB:3BOM"
FT TURN 78..80
FT /evidence="ECO:0007829|PDB:2R1H"
FT HELIX 82..85
FT /evidence="ECO:0007829|PDB:3BOM"
FT HELIX 87..95
FT /evidence="ECO:0007829|PDB:3BOM"
FT HELIX 102..123
FT /evidence="ECO:0007829|PDB:3BOM"
FT HELIX 126..144
FT /evidence="ECO:0007829|PDB:3BOM"
SQ SEQUENCE 148 AA; 16140 MW; B8F24E8618DEB936 CRC64;
MVDWTDPERS AIVGLWGKIS VDEIGPQALA RLLIVSPWTQ RHFSTFGNLS TPAAIMGNPA
VAKHGKTVMH GLDRAVQNLD DIKNTYTALS VMHSEKLHVD PDNFRLLADC ITVCVAAKLG
PAVFSADTQE AFQKFLAVVV SALGRQYH
