HBBA_ANGAN
ID HBBA_ANGAN Reviewed; 147 AA.
AC P80946;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Hemoglobin anodic subunit beta;
DE AltName: Full=Hemoglobin anodic beta chain;
GN Name=hbb1;
OS Anguilla anguilla (European freshwater eel) (Muraena anguilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Anguilliformes; Anguillidae;
OC Anguilla.
OX NCBI_TaxID=7936;
RN [1]
RP PROTEIN SEQUENCE.
RC TISSUE=Erythrocyte;
RX PubMed=9188451; DOI=10.1074/jbc.272.25.15628;
RA Fago A., Bendixen E., Malte H., Weber R.E.;
RT "The anodic hemoglobin of Anguilla anguilla. Molecular basis for allosteric
RT effects in a root-effect hemoglobin.";
RL J. Biol. Chem. 272:15628-15635(1997).
CC -!- FUNCTION: Involved in oxygen transport from gills to the various
CC peripheral tissues.
CC -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC -!- TISSUE SPECIFICITY: Red blood cells.
CC -!- MISCELLANEOUS: This fish has two hemoglobins: cathodic and anodic. The
CC cathodic Hb and anodic Hb display small and large Bohr effects
CC respectively. In addition, the cathodic Hb displays a reverse Bohr
CC effect and appreciable phosphate effects.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
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DR AlphaFoldDB; P80946; -.
DR SMR; P80946; -.
DR PRIDE; P80946; -.
DR GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR CDD; cd08925; Hb-beta-like; 1.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002337; Hemoglobin_b.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00814; BETAHAEM.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW Transport.
FT CHAIN 1..147
FT /note="Hemoglobin anodic subunit beta"
FT /id="PRO_0000052870"
FT BINDING 63
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT BINDING 92
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
SQ SEQUENCE 147 AA; 16770 MW; C447A8450208969F CRC64;
VEWTEDERTA IKSKWLKINI EEIGPQAMRR LLIVCPWTQR HFANFGNLST AAAIMNNDKV
AKHGTTVMGG LDRAIQNMDD IKNAYRQLSV MHSEKLHVDP DNFRLLAEHI TLCMAAKFGP
TEFTADVQEA WQKFLMAVTS ALARQYH