ID   HBBA_BOSJA              Reviewed;         145 AA.
AC   P04346;
DT   20-MAR-1987, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-1987, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Hemoglobin subunit beta-A;
DE   AltName: Full=Beta-A-globin;
DE   AltName: Full=Hemoglobin beta-A chain;
OS   Bos javanicus (Wild banteng).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9906;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=6626147; DOI=10.1007/bf00498925;
RA   Namikawa T., Takenaka O., Takahashi K.;
RT   "Hemoglobin Bali (bovine): beta A 18(Bl)Lys leads to His: one of the
RT   'missing links' between beta A and beta B of domestic cattle exists in the
RT   Bali cattle (Bovinae, Box banteng).";
RL   Biochem. Genet. 21:787-796(1983).
CC   -!- FUNCTION: Involved in oxygen transport from the lung to the various
CC       peripheral tissues.
CC   -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC   -!- TISSUE SPECIFICITY: Red blood cells.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   PIR; A02388; HBBOBB.
DR   AlphaFoldDB; P04346; -.
DR   SMR; P04346; -.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd08925; Hb-beta-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002337; Hemoglobin_b.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00814; BETAHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW   Transport.
FT   CHAIN           1..145
FT                   /note="Hemoglobin subunit beta-A"
FT                   /id="PRO_0000052890"
FT   BINDING         62
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT   BINDING         91
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
SQ   SEQUENCE   145 AA;  15964 MW;  52685BDC8CDFBDD5 CRC64;
     MLTAEEKAAV TAFWGKVHVD EVGGEALGRL LVVYPWTQRF FESFGDLSTA DAVMNNPKVK
     AHGKKVLDSF SDGMKHLDDL KGTFAALSEL HCDKLHVDPE NFKLLGNVLV VVLARNFGKE
     FTPVLQADFQ KVVAGVANAL AHRYH