HBBC_CAPHI
ID HBBC_CAPHI Reviewed; 142 AA.
AC P02078; Q28326;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Hemoglobin subunit beta-C;
DE AltName: Full=Beta-C-globin;
DE AltName: Full=Cysteine beta-globin;
DE AltName: Full=Hemoglobin beta-C chain;
GN Name=HBBC;
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6277503; DOI=10.1016/0092-8674(81)90419-0;
RA Schon E.A., Cleary M.L., Haynes J.R., Lingrel J.B.;
RT "Structure and evolution of goat gamma-, beta C- and beta A-globin genes:
RT three developmentally regulated genes contain inserted elements.";
RL Cell 27:359-369(1981).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 67-135.
RX PubMed=6248519; DOI=10.1016/s0021-9258(18)43745-3;
RA Haynes J.R., Rosteck P.R. Jr., Schon E.A., Gallagher P.M., Burks D.J.,
RA Smith K., Lingrel J.B.;
RT "The isolation of the beta A-, beta C-, and gamma-globin genes and a
RT presumptive embryonic globin gene from a goat DNA recombinant library.";
RL J. Biol. Chem. 255:6355-6367(1980).
CC -!- FUNCTION: Involved in oxygen transport from the lung to the various
CC peripheral tissues.
CC -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC -!- TISSUE SPECIFICITY: Red blood cells.
CC -!- MISCELLANEOUS: This type of beta-C chain is found when anemia has been
CC experimentally produced.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
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DR EMBL; M15389; AAA30914.1; ALT_SEQ; Genomic_DNA.
DR EMBL; K00662; AAA30921.1; -; Genomic_DNA.
DR EMBL; K00661; AAA30921.1; JOINED; Genomic_DNA.
DR PIR; B02396; HBGTC.
DR RefSeq; XP_005689870.1; XM_005689813.2.
DR AlphaFoldDB; P02078; -.
DR SMR; P02078; -.
DR STRING; 9925.ENSCHIP00000028862; -.
DR Ensembl; ENSCHIT00000036686; ENSCHIP00000028816; ENSCHIG00000024184.
DR GeneID; 102175045; -.
DR KEGG; chx:102175045; -.
DR CTD; 102175045; -.
DR GeneTree; ENSGT00940000156216; -.
DR OMA; SQLHCEK; -.
DR OrthoDB; 1370439at2759; -.
DR Proteomes; UP000291000; Chromosome 15.
DR Bgee; ENSCHIG00000024184; Expressed in metanephros cortex and 16 other tissues.
DR GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR CDD; cd08925; Hb-beta-like; 1.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002337; Hemoglobin_b.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00814; BETAHAEM.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 2: Evidence at transcript level;
KW Heme; Iron; Metal-binding; Oxygen transport; Reference proteome; Transport.
FT CHAIN 1..142
FT /note="Hemoglobin subunit beta-C"
FT /id="PRO_0000052910"
FT BINDING 59
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT BINDING 88
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
SQ SEQUENCE 142 AA; 15751 MW; 116CEA369EBD0A33 CRC64;
MPNKALITGF WSKVKVDEVG AEALGRLLVV YPWTQRFFEH FGDLSSADAV LGNAKVKAHG
KKVLDSFSNG VQHLDDLKGT FAELSELHCD KLHVDPENFR LLGNVLVIVL ARHFGKEFTP
ELQAEFQKVV AGVASALAHR YH
