HBBC_OPHSE
ID HBBC_OPHSE Reviewed; 146 AA.
AC B3EWR8;
DT 16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT 16-OCT-2013, sequence version 1.
DT 03-AUG-2022, entry version 16.
DE RecName: Full=Hemoglobin cathodic subunit beta {ECO:0000303|PubMed:23632627};
DE AltName: Full=Hemoglobin cathodic beta chain {ECO:0000303|PubMed:23632627};
OS Ophisurus serpens (Serpent eel) (Muraena serpens).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Anguilliformes; Ophichthidae;
OC Ophisurus.
OX NCBI_TaxID=1234705;
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, FUNCTION, TISSUE SPECIFICITY, AND MASS SPECTROMETRY.
RC TISSUE=Erythrocyte {ECO:0000269|PubMed:23632627};
RX PubMed=23632627; DOI=10.1007/s00360-013-0759-y;
RA Manconi B., Pellegrini M., Messana I., Sanna M.T., Castagnola M.,
RA Iavarone F., Coluccia E., Giardina B., Olianas A.;
RT "The hemoglobin system of the serpent eel Ophisurus serpens: structural and
RT functional characterization.";
RL J. Comp. Physiol. B 183:905-919(2013).
CC -!- FUNCTION: Involved in oxygen transport from the gills to various
CC peripheral tissues. {ECO:0000305|PubMed:23632627}.
CC -!- SUBUNIT: Heterotetramer of two alpha and two beta chains.
CC {ECO:0000250|UniProtKB:P29623}.
CC -!- TISSUE SPECIFICITY: Red blood cells. {ECO:0000269|PubMed:23632627}.
CC -!- MASS SPECTROMETRY: Mass=16004; Mass_error=3; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:23632627};
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR GO; GO:0005833; C:hemoglobin complex; IDA:UniProtKB.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019825; F:oxygen binding; IDA:UniProtKB.
DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR CDD; cd08925; Hb-beta-like; 1.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002337; Hemoglobin_b.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00814; BETAHAEM.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW Transport.
FT CHAIN 1..146
FT /note="Hemoglobin cathodic subunit beta"
FT /id="PRO_0000423888"
FT BINDING 63
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT /evidence="ECO:0000250|UniProtKB:P29623,
FT ECO:0000255|PROSITE-ProRule:PRU00238"
FT UNSURE 11
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:23632627"
FT UNSURE 14
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:23632627"
FT UNSURE 28
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:23632627"
FT UNSURE 31
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:23632627"
FT UNSURE 32
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:23632627"
FT UNSURE 34
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:23632627"
FT UNSURE 48
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:23632627"
FT UNSURE 54
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:23632627"
FT UNSURE 67
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:23632627"
FT UNSURE 68
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:23632627"
FT UNSURE 69
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:23632627"
FT UNSURE 72
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:23632627"
FT UNSURE 84
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:23632627"
FT UNSURE 96
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:23632627"
FT UNSURE 105
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:23632627"
FT UNSURE 106
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:23632627"
FT UNSURE 110
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:23632627"
FT UNSURE 112
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:23632627"
FT UNSURE 114
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:23632627"
FT UNSURE 141
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:23632627"
SQ SEQUENCE 146 AA; 15990 MW; 9F0AD6524CBF84EB CRC64;
VQWSSSERSV ISGLWAKVNA AEVGPQALAR LLVLYPWTQR YFGKFGDLSS NAALMGNANV
AKHGKDLLLA DLKAVKNMDN VKALYAKXXX XXXXELNVDP DNFTLLGDCL TIVLAMKFGA
DFTPVDQAVW QKFVAVVVSG LSKQYF
