ID   HBBC_TREBE              Reviewed;         146 AA.
AC   P45722;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Hemoglobin subunit beta-C;
DE   AltName: Full=Beta-C-globin;
DE   AltName: Full=Hemoglobin beta-C chain;
GN   Name=hbbc;
OS   Trematomus bernacchii (Emerald rockcod) (Pseudotrematomus bernacchii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Notothenioidei; Nototheniidae; Trematomus.
OX   NCBI_TaxID=40690;
RN   [1]
RP   PROTEIN SEQUENCE, AND SUBUNIT.
RX   PubMed=8144556; DOI=10.1016/s0021-9258(17)36935-1;
RA   D'Avino R., Caruso C., Tamburrini M., Romano M., Rutigliano B.,
RA   Polverino de Laureto P., Camardella L., Carratore V., di Prisco G.;
RT   "Molecular characterization of the functionally distinct hemoglobins of the
RT   Antarctic fish Trematomus newnesi.";
RL   J. Biol. Chem. 269:9675-9681(1994).
CC   -!- FUNCTION: Involved in oxygen transport from gills to the various
CC       peripheral tissues.
CC   -!- SUBUNIT: HbC is a heterotetramer of two alpha chains and two beta-C
CC       chains. {ECO:0000269|PubMed:8144556}.
CC   -!- TISSUE SPECIFICITY: Red blood cells.
CC   -!- MISCELLANEOUS: This fish has three hemoglobins: Hb1 (major) and two
CC       minor hemoglobins (about 1-2% of the total).
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   PIR; E54403; E54403.
DR   AlphaFoldDB; P45722; -.
DR   SMR; P45722; -.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd08925; Hb-beta-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002337; Hemoglobin_b.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00814; BETAHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW   Transport.
FT   CHAIN           1..146
FT                   /note="Hemoglobin subunit beta-C"
FT                   /id="PRO_0000053047"
FT   BINDING         63
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT   BINDING         92
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
SQ   SEQUENCE   146 AA;  16351 MW;  990E4DAA62AFF0A6 CRC64;
     VEWTDFERAT IKDIFSKLEY DVVGPATLAR CLVVYPWTQR YFGKFGNLYN ATAIAENAMV
     SKHGTTILHG LDRAVKNMDD IKNTYAELSV LHSEKLHVDP DNFKLLADCL TIVVAARFGS
     AFTGEVQAAF EKFMAVVVSS LGRQYH