ID   HBBF_BOVIN              Reviewed;         145 AA.
AC   P02081; Q3SX09;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 161.
DE   RecName: Full=Hemoglobin fetal subunit beta;
DE   AltName: Full=Beta-globin, fetal;
DE   AltName: Full=Hemoglobin beta chain, fetal;
DE   AltName: Full=Hemoglobin gamma chain;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=5958205; DOI=10.1021/bi00868a025;
RA   Babin D.R., Schroeder W.A., Shelton J.R., Shelton J.B., Robberson B.;
RT   "The amino acid sequence of the gamma chain of bovine fetal hemoglobin.";
RL   Biochemistry 5:1297-1310(1966).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6322113; DOI=10.1093/nar/12.3.1641;
RA   Schimenti J.C., Duncan C.H.;
RT   "Ruminant globin gene structures suggest an evolutionary role for Alu-type
RT   repeats.";
RL   Nucleic Acids Res. 12:1641-1655(1984).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in oxygen transport from the lung to the various
CC       peripheral tissues.
CC   -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC   -!- TISSUE SPECIFICITY: Red blood cells.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   EMBL; X00354; CAA25101.1; -; Genomic_DNA.
DR   EMBL; M63452; AAA30519.1; -; Genomic_DNA.
DR   EMBL; BC104565; AAI04566.2; -; mRNA.
DR   PIR; A93504; HBBOF.
DR   RefSeq; NP_001014902.1; NM_001014902.3.
DR   RefSeq; NP_001103979.1; NM_001110509.2.
DR   AlphaFoldDB; P02081; -.
DR   SMR; P02081; -.
DR   STRING; 9913.ENSBTAP00000043063; -.
DR   PaxDb; P02081; -.
DR   PeptideAtlas; P02081; -.
DR   PRIDE; P02081; -.
DR   Ensembl; ENSBTAT00000045694; ENSBTAP00000043063; ENSBTAG00000038748.
DR   GeneID; 511735; -.
DR   KEGG; bta:511735; -.
DR   CTD; 511735; -.
DR   VEuPathDB; HostDB:ENSBTAG00000038748; -.
DR   eggNOG; KOG3378; Eukaryota.
DR   GeneTree; ENSGT00940000156216; -.
DR   HOGENOM; CLU_003827_10_0_1; -.
DR   InParanoid; P02081; -.
DR   OMA; HITLCMA; -.
DR   OrthoDB; 1370439at2759; -.
DR   TreeFam; TF333268; -.
DR   Proteomes; UP000009136; Chromosome 15.
DR   Bgee; ENSBTAG00000038748; Expressed in floor plate of diencephalon and 60 other tissues.
DR   GO; GO:0031838; C:haptoglobin-hemoglobin complex; IBA:GO_Central.
DR   GO; GO:0005833; C:hemoglobin complex; IBA:GO_Central.
DR   GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR   GO; GO:0031721; F:hemoglobin alpha binding; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0043177; F:organic acid binding; IBA:GO_Central.
DR   GO; GO:0019825; F:oxygen binding; IBA:GO_Central.
DR   GO; GO:0005344; F:oxygen carrier activity; IBA:GO_Central.
DR   GO; GO:0098869; P:cellular oxidant detoxification; IEA:GOC.
DR   GO; GO:0042744; P:hydrogen peroxide catabolic process; IBA:GO_Central.
DR   CDD; cd08925; Hb-beta-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002337; Hemoglobin_b.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00814; BETAHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..145
FT                   /note="Hemoglobin fetal subunit beta"
FT                   /id="PRO_0000052893"
FT   BINDING         62
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT   BINDING         91
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
SQ   SEQUENCE   145 AA;  15859 MW;  78B8722915E9C221 CRC64;
     MLSAEEKAAV TSLFAKVKVD EVGGEALGRL LVVYPWTQRF FESFGDLSSA DAILGNPKVK
     AHGKKVLDSF CEGLKQLDDL KGAFASLSEL HCDKLHVDPE NFRLLGNVLV VVLARRFGSE
     FSPELQASFQ KVVTGVANAL AHRYH