HBBF_SHEEP
ID HBBF_SHEEP Reviewed; 145 AA.
AC P02083;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Hemoglobin fetal subunit beta;
DE AltName: Full=Beta-globin, fetal;
DE AltName: Full=Hemoglobin beta chain, fetal;
DE AltName: Full=Hemoglobin gamma chain;
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-29; 52-96 AND 104-145.
RX PubMed=6161931; DOI=10.1016/s0021-9258(19)69903-5;
RA Kretschmer P.J., Coon H.C., Davis A., Harrison M., Nienhuis A.W.;
RT "Hemoglobin switching in sheep. Isolation of the fetal gamma-globin gene
RT and demonstration that the fetal gamma- and adult beta A-globin genes lie
RT within eight kilobase segments of homologous DNA.";
RL J. Biol. Chem. 256:1975-1982(1981).
RN [2]
RP PROTEIN SEQUENCE.
RX PubMed=974104; DOI=10.1016/0005-2795(76)90092-1;
RA Darbre P.D., Lehmann H.;
RT "The gamma chain of the lamb.";
RL Biochim. Biophys. Acta 446:10-18(1976).
CC -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
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DR EMBL; K02824; AAA31533.1; -; Genomic_DNA.
DR EMBL; K02825; AAA31534.1; -; Genomic_DNA.
DR EMBL; K02826; AAA31535.1; -; Genomic_DNA.
DR PIR; B92306; HGSH.
DR RefSeq; XP_004016290.1; XM_004016241.2.
DR AlphaFoldDB; P02083; -.
DR SMR; P02083; -.
DR STRING; 9940.ENSOARP00000020597; -.
DR PRIDE; P02083; -.
DR Ensembl; ENSOART00020006913; ENSOARP00020005712; ENSOARG00020004525.
DR GeneID; 101106199; -.
DR KEGG; oas:101106199; -.
DR eggNOG; KOG3378; Eukaryota.
DR OMA; SADAIMH; -.
DR OrthoDB; 1370439at2759; -.
DR Proteomes; UP000002356; Unplaced.
DR GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR CDD; cd08925; Hb-beta-like; 1.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002337; Hemoglobin_b.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00814; BETAHAEM.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW Reference proteome; Transport.
FT CHAIN 1..145
FT /note="Hemoglobin fetal subunit beta"
FT /id="PRO_0000053107"
FT BINDING 62
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT BINDING 91
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
FT CONFLICT 119..120
FT /note="GE -> EG (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 145 AA; 15931 MW; 9924A27CCBC34C28 CRC64;
MLTAEEKASV ISLFAKVNVE EVGGEALGRL LVVYPWTQRF FEHFGDLSSA DAILGNPKVK
GHGKKVLNSF SEGLKQLDDL KGAFASLSEL HCDKLHVDPE NFRLLGNVLV VVLARRFGGE
FTPELQANFQ KVVTGVANAL AHRYH
