ID   HBBL_XENLA              Reviewed;         147 AA.
AC   P02137; Q5D093;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Hemoglobin larval subunit beta-1;
DE   AltName: Full=Beta-1-globin;
DE   AltName: Full=Hemoglobin beta-1 chain, larval;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=6688076; DOI=10.1016/s0021-9258(20)82006-7;
RA   Banville D., Kay R.M., Harris R., Williams J.G.;
RT   "The nucleotide sequence of the mRNA encoding a tadpole beta-globin
RT   polypeptide of Xenopus laevis.";
RL   J. Biol. Chem. 258:7924-7927(1983).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6093050; DOI=10.1093/nar/12.20.7705;
RA   Meyerhof W., Klinger-Mitropoulos S., Stalder J., Weber R., Knoechel W.;
RT   "The primary structure of the larval beta 1-globin gene of Xenopus laevis
RT   and its flanking regions.";
RL   Nucleic Acids Res. 12:7705-7719(1984).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2999708; DOI=10.1093/nar/13.21.7899;
RA   Knoechel W., Meyerhof W., Stalder J., Weber R.;
RT   "Comparative nucleotide sequence analysis of two types of larval beta-
RT   globin mRNAs of Xenopus laevis.";
RL   Nucleic Acids Res. 13:7899-7908(1985).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This is a larval (tadpole) beta-globin.
CC   -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC   -!- TISSUE SPECIFICITY: Red blood cells.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   EMBL; X03143; CAA26915.1; -; mRNA.
DR   EMBL; X01084; CAA25562.1; -; Genomic_DNA.
DR   EMBL; BC053807; AAH53807.1; -; mRNA.
DR   PIR; A02457; HBXLT1.
DR   PIR; I51600; I51600.
DR   RefSeq; NP_001079742.1; NM_001086273.2.
DR   AlphaFoldDB; P02137; -.
DR   SMR; P02137; -.
DR   DNASU; 379431; -.
DR   GeneID; 379431; -.
DR   KEGG; xla:379431; -.
DR   CTD; 379431; -.
DR   Xenbase; XB-GENE-5844733; hbd.S.
DR   OMA; HITLCMA; -.
DR   OrthoDB; 1370439at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10S.
DR   Bgee; 379431; Expressed in internal ear and 8 other tissues.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd08925; Hb-beta-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002337; Hemoglobin_b.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00814; BETAHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   2: Evidence at transcript level;
KW   Heme; Iron; Metal-binding; Oxygen transport; Reference proteome; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT   CHAIN           2..147
FT                   /note="Hemoglobin larval subunit beta-1"
FT                   /id="PRO_0000053157"
FT   BINDING         64
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT   BINDING         93
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT   CONFLICT        108
FT                   /note="A -> G (in Ref. 1)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   147 AA;  16047 MW;  E804934D3DF0EAB9 CRC64;
     MVHLSADEKS AINAVWSKVN IENDGHDALT RLLVVFPWTQ RYFSSFGNLS NVAAISGNAK
     VRAHGKKVLS AVDESIHHLD DIKNFLSVLS TKHAEELHVD PENFKRLADV LVIVLAGKLG
     AAFTPQVQAA WEKFSAGLVA ALSHGYF