ID   HBB_ANSIN               Reviewed;         146 AA.
AC   P02118;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Hemoglobin subunit beta;
DE   AltName: Full=Beta-globin;
DE   AltName: Full=Hemoglobin beta chain;
GN   Name=HBB;
OS   Anser indicus (Bar-headed goose) (Anas indica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anserinae; Anser.
OX   NCBI_TaxID=8846;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=7106705;
RA   Oberthur W., Braunitzer G., Wurdinger I.;
RT   "Hemoglobins, XLVII. Hemoglobins of the bar-headed goose (Anser indicus):
RT   primary structure and physiology of respiration, systematic and
RT   evolution.";
RL   Hoppe-Seyler's Z. Physiol. Chem. 363:581-590(1982).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
RX   PubMed=8568892; DOI=10.1006/jmbi.1996.0040;
RA   Zhang J., Hua Z., Tame J.R.H., Lu G., Zhang R., Gu X.;
RT   "The crystal structure of a high oxygen affinity species of haemoglobin
RT   (bar-headed goose haemoglobin in the oxy form).";
RL   J. Mol. Biol. 255:484-493(1996).
CC   -!- FUNCTION: Involved in oxygen transport from the lung to the various
CC       peripheral tissues.
CC   -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC   -!- TISSUE SPECIFICITY: Red blood cells.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   PIR; A02438; HBGSI.
DR   PDB; 1A4F; X-ray; 2.00 A; B=1-146.
DR   PDB; 1C40; X-ray; 2.30 A; B=1-146.
DR   PDB; 1HV4; X-ray; 2.80 A; B/D/F/H=1-146.
DR   PDBsum; 1A4F; -.
DR   PDBsum; 1C40; -.
DR   PDBsum; 1HV4; -.
DR   AlphaFoldDB; P02118; -.
DR   SMR; P02118; -.
DR   MINT; P02118; -.
DR   EvolutionaryTrace; P02118; -.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd08925; Hb-beta-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002337; Hemoglobin_b.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00814; BETAHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Direct protein sequencing; Heme; Iron; Metal-binding;
KW   Oxygen transport; Transport.
FT   CHAIN           1..146
FT                   /note="Hemoglobin subunit beta"
FT                   /id="PRO_0000052873"
FT   BINDING         63
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT   BINDING         92
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT   HELIX           5..15
FT                   /evidence="ECO:0007829|PDB:1A4F"
FT   HELIX           20..34
FT                   /evidence="ECO:0007829|PDB:1A4F"
FT   HELIX           36..45
FT                   /evidence="ECO:0007829|PDB:1A4F"
FT   HELIX           51..55
FT                   /evidence="ECO:0007829|PDB:1A4F"
FT   HELIX           58..76
FT                   /evidence="ECO:0007829|PDB:1A4F"
FT   TURN            77..79
FT                   /evidence="ECO:0007829|PDB:1A4F"
FT   HELIX           81..94
FT                   /evidence="ECO:0007829|PDB:1A4F"
FT   HELIX           101..118
FT                   /evidence="ECO:0007829|PDB:1A4F"
FT   HELIX           119..121
FT                   /evidence="ECO:0007829|PDB:1A4F"
FT   HELIX           124..141
FT                   /evidence="ECO:0007829|PDB:1A4F"
FT   TURN            143..145
FT                   /evidence="ECO:0007829|PDB:1HV4"
SQ   SEQUENCE   146 AA;  16291 MW;  473E9A70E5602A53 CRC64;
     VHWSAEEKQL ITGLWGKVNV ADCGAEALAR LLIVYPWTQR FFSSFGNLSS PTAILGNPMV
     RAHGKKVLTS FGDAVKNLDN IKNTFAQLSE LHCDKLHVDP ENFRLLGDIL IIVLAAHFAK
     EFTPDCQAAW QKLVRVVAHA LARKYH