ID   HBB_CAICR               Reviewed;         146 AA.
AC   P02131;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Hemoglobin subunit beta;
DE   AltName: Full=Beta-globin;
DE   AltName: Full=Hemoglobin beta chain;
GN   Name=HBB;
OS   Caiman crocodilus (Spectacled caiman) (Caiman sclerops).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Caimaninae; Caiman.
OX   NCBI_TaxID=8499;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=6286445;
RA   Leclercq F., Schnek A.G., Braunitzer G., Stangl A., Schrank B.;
RT   "Direct reciprocal allosteric interaction of oxygen and hydrogen carbonate
RT   sequence of the haemoglobins of the Caiman (Caiman crocodylus), the Nile
RT   crocodile (Crocodylus niloticus) and the Mississippi crocodile (Alligator
RT   mississippiensis).";
RL   Hoppe-Seyler's Z. Physiol. Chem. 362:1151-1158(1981).
CC   -!- FUNCTION: Involved in oxygen transport from the lung to the various
CC       peripheral tissues.
CC   -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC   -!- TISSUE SPECIFICITY: Red blood cells.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   PIR; A02451; HBCQ.
DR   AlphaFoldDB; P02131; -.
DR   SMR; P02131; -.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd08925; Hb-beta-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002337; Hemoglobin_b.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00814; BETAHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW   Transport.
FT   CHAIN           1..146
FT                   /note="Hemoglobin subunit beta"
FT                   /id="PRO_0000052899"
FT   BINDING         63
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT   BINDING         92
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
SQ   SEQUENCE   146 AA;  16718 MW;  A224788EEDE940B4 CRC64;
     SPFSAHEEKL IVDLWAKVDV ASCGGDALSR MLIIYPWKRR YFEHFGKLST DQDVLHNEKI
     REHGKKVLAS FGEAVKHLDN IKGHFAHLSK LHFEKFHVDC ENFKLLGDII IVVLGMHHPK
     DFTLQTHAAF QKLVRHVAAA LSAEYH