ID   HBB_CAVPO               Reviewed;         146 AA.
AC   P02095;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Hemoglobin subunit beta;
DE   AltName: Full=Beta-globin;
DE   AltName: Full=Hemoglobin beta chain;
GN   Name=HBB;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=527943;
RA   Braunitzer G., Schrank B., Stangl A., Wiesner H.;
RT   "Respiration at high altitudes, phosphate-protein interaction: the sequence
RT   of hemoglobins from guinea pig and dromedary.";
RL   Hoppe-Seyler's Z. Physiol. Chem. 360:1941-1946(1979).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (1.67 ANGSTROMS), AND SUBUNIT.
RX   PubMed=20811494; DOI=10.1371/journal.pone.0012389;
RA   Pairet B., Jaenicke E.;
RT   "Structure of the altitude adapted hemoglobin of guinea pig in the R2-
RT   state.";
RL   PLoS ONE 5:E12389-E12389(2010).
CC   -!- FUNCTION: Involved in oxygen transport from the lung to the various
CC       peripheral tissues.
CC   -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC       {ECO:0000269|PubMed:20811494}.
CC   -!- TISSUE SPECIFICITY: Red blood cells.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   PIR; A02411; HBGP.
DR   PDB; 3A0G; X-ray; 2.50 A; B=1-146.
DR   PDB; 3HYU; X-ray; 1.67 A; B=1-146.
DR   PDBsum; 3A0G; -.
DR   PDBsum; 3HYU; -.
DR   AlphaFoldDB; P02095; -.
DR   SMR; P02095; -.
DR   STRING; 10141.ENSCPOP00000001378; -.
DR   eggNOG; KOG3378; Eukaryota.
DR   InParanoid; P02095; -.
DR   EvolutionaryTrace; P02095; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd08925; Hb-beta-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002337; Hemoglobin_b.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00814; BETAHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Acetylation; Direct protein sequencing; Heme; Iron;
KW   Metal-binding; Oxygen transport; Reference proteome; S-nitrosylation;
KW   Transport.
FT   CHAIN           1..146
FT                   /note="Hemoglobin subunit beta"
FT                   /id="PRO_0000052915"
FT   BINDING         63
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT   BINDING         92
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT   MOD_RES         1
FT                   /note="N-acetylvaline"
FT                   /evidence="ECO:0000250|UniProtKB:P02086"
FT   MOD_RES         82
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P68871"
FT   MOD_RES         93
FT                   /note="S-nitrosocysteine"
FT                   /evidence="ECO:0000250|UniProtKB:P68871"
FT   MOD_RES         144
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P68871"
FT   HELIX           5..15
FT                   /evidence="ECO:0007829|PDB:3HYU"
FT   HELIX           20..34
FT                   /evidence="ECO:0007829|PDB:3HYU"
FT   HELIX           36..45
FT                   /evidence="ECO:0007829|PDB:3HYU"
FT   HELIX           51..56
FT                   /evidence="ECO:0007829|PDB:3HYU"
FT   HELIX           58..74
FT                   /evidence="ECO:0007829|PDB:3HYU"
FT   HELIX           75..80
FT                   /evidence="ECO:0007829|PDB:3A0G"
FT   HELIX           81..84
FT                   /evidence="ECO:0007829|PDB:3HYU"
FT   HELIX           86..94
FT                   /evidence="ECO:0007829|PDB:3HYU"
FT   HELIX           101..117
FT                   /evidence="ECO:0007829|PDB:3HYU"
FT   TURN            119..121
FT                   /evidence="ECO:0007829|PDB:3HYU"
FT   HELIX           124..141
FT                   /evidence="ECO:0007829|PDB:3HYU"
FT   HELIX           143..145
FT                   /evidence="ECO:0007829|PDB:3HYU"
SQ   SEQUENCE   146 AA;  15921 MW;  E880DAC410019685 CRC64;
     VHLTAAEKSA ILDLWGKVNV GEIGAEALGR LLVVYPWTQR FFEKFGDLSS ASAIMSNAHV
     KSHGAKVLAS FSEGLKHLQD LKGTFAKLSE LHCDKLHVDP ENFRLLGNMI VIALAHHHPS
     EFTPCTQAAF QKVTAGVANA LAHKYH