AN33B_MOUSE
ID AN33B_MOUSE Reviewed; 486 AA.
AC Q3U0L2; Q8BJA8; Q9CYB2; Q9CZ88; Q9DCQ8;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Ankyrin repeat domain-containing protein 33B;
GN Name=Ankrd33b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4).
RC STRAIN=C57BL/6J, and NOD; TISSUE=Embryo, Kidney, and Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-397, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Heart, and Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q3U0L2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3U0L2-2; Sequence=VSP_032778;
CC Name=3;
CC IsoId=Q3U0L2-3; Sequence=VSP_032781, VSP_032782;
CC Name=4;
CC IsoId=Q3U0L2-4; Sequence=VSP_032779, VSP_032780;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK002572; BAB22197.1; -; mRNA.
DR EMBL; AK012871; BAB28525.1; -; mRNA.
DR EMBL; AK017844; BAB30970.1; -; mRNA.
DR EMBL; AK089667; BAC40941.1; -; mRNA.
DR EMBL; AK156757; BAE33840.1; -; mRNA.
DR EMBL; AK170894; BAE42099.1; -; mRNA.
DR CCDS; CCDS27408.1; -. [Q3U0L2-2]
DR CCDS; CCDS27409.1; -. [Q3U0L2-4]
DR CCDS; CCDS49589.1; -. [Q3U0L2-1]
DR RefSeq; NP_001157913.1; NM_001164441.1. [Q3U0L2-1]
DR RefSeq; NP_080429.1; NM_026153.3. [Q3U0L2-4]
DR RefSeq; NP_081772.1; NM_027496.3. [Q3U0L2-2]
DR AlphaFoldDB; Q3U0L2; -.
DR SMR; Q3U0L2; -.
DR STRING; 10090.ENSMUSP00000118984; -.
DR iPTMnet; Q3U0L2; -.
DR PhosphoSitePlus; Q3U0L2; -.
DR jPOST; Q3U0L2; -.
DR PaxDb; Q3U0L2; -.
DR PeptideAtlas; Q3U0L2; -.
DR PRIDE; Q3U0L2; -.
DR ProteomicsDB; 296285; -. [Q3U0L2-1]
DR ProteomicsDB; 296286; -. [Q3U0L2-2]
DR ProteomicsDB; 296287; -. [Q3U0L2-3]
DR ProteomicsDB; 296288; -. [Q3U0L2-4]
DR Antibodypedia; 58746; 11 antibodies from 7 providers.
DR Ensembl; ENSMUST00000076942; ENSMUSP00000076209; ENSMUSG00000022237. [Q3U0L2-4]
DR Ensembl; ENSMUST00000110410; ENSMUSP00000106040; ENSMUSG00000022237. [Q3U0L2-2]
DR Ensembl; ENSMUST00000123325; ENSMUSP00000118984; ENSMUSG00000022237. [Q3U0L2-1]
DR Ensembl; ENSMUST00000156679; ENSMUSP00000117974; ENSMUSG00000022237. [Q3U0L2-3]
DR GeneID; 67434; -.
DR KEGG; mmu:67434; -.
DR UCSC; uc007vkd.3; mouse. [Q3U0L2-1]
DR UCSC; uc007vke.3; mouse. [Q3U0L2-2]
DR UCSC; uc007vkf.2; mouse. [Q3U0L2-4]
DR CTD; 651746; -.
DR MGI; MGI:1917904; Ankrd33b.
DR VEuPathDB; HostDB:ENSMUSG00000022237; -.
DR eggNOG; ENOG502QT8J; Eukaryota.
DR GeneTree; ENSGT00500000044852; -.
DR HOGENOM; CLU_049994_1_0_1; -.
DR InParanoid; Q3U0L2; -.
DR OMA; DTYSLEW; -.
DR OrthoDB; 1045586at2759; -.
DR PhylomeDB; Q3U0L2; -.
DR TreeFam; TF332022; -.
DR BioGRID-ORCS; 67434; 1 hit in 75 CRISPR screens.
DR ChiTaRS; Ankrd33b; mouse.
DR PRO; PR:Q3U0L2; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q3U0L2; protein.
DR Bgee; ENSMUSG00000022237; Expressed in retinal neural layer and 136 other tissues.
DR ExpressionAtlas; Q3U0L2; baseline and differential.
DR Genevisible; Q3U0L2; MM.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR Pfam; PF12796; Ank_2; 1.
DR SMART; SM00248; ANK; 4.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; ANK repeat; Coiled coil; DNA-binding; Phosphoprotein;
KW Reference proteome; Repeat.
FT CHAIN 1..486
FT /note="Ankyrin repeat domain-containing protein 33B"
FT /id="PRO_0000328770"
FT REPEAT 80..109
FT /note="ANK 1"
FT REPEAT 116..146
FT /note="ANK 2"
FT REPEAT 150..179
FT /note="ANK 3"
FT REPEAT 185..214
FT /note="ANK 4"
FT REPEAT 219..251
FT /note="ANK 5"
FT REGION 1..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 353..394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 426..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 451..479
FT /evidence="ECO:0000255"
FT COMPBIAS 353..392
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..479
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 397
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 110..118
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_032778"
FT VAR_SEQ 119..128
FT /note="TGLIVACYHG -> GSAAGPYGLR (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_032779"
FT VAR_SEQ 129..486
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_032780"
FT VAR_SEQ 162..190
FT /note="GHVTITNYLLNYFPGLDLERRNIFGFTAL -> VCACAPHTCHAKGGQKRAL
FT DPLELQLLDG (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_032781"
FT VAR_SEQ 191..486
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_032782"
FT CONFLICT 78
FT /note="G -> A (in Ref. 1; BAB28525)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 486 AA; 53203 MW; 307C343866B6BAC8 CRC64;
MVLLAGPGPE GGGTRCLSPQ SPTPPRSEQT GEDPADYEEY EDFSSLPDTR SIASDDSFYP
PGGEEEYGSV SAESVPEGVP EAATLLRAAC ANDVGLLRAL VRRGPSSEEV RETDRNGRTG
LIVACYHGFV DTVVALAECP HVDVNWQDSE GNTALITAAQ AGHVTITNYL LNYFPGLDLE
RRNIFGFTAL MKAAMQGRTE CVRALMMAGA DVQARDPRRG LSPQEWAAYT GRAEAVRVIQ
RLMERPCPEQ FGDKYKLELP LPAEAVLKKS GSKNCLQRFT AFLRSTLTSR SSGQSLEDGG
VLDHMVRMTT SLYSPAVAVV CQTVCPENPP CVGKRRLAVQ EILAARGNLN AQAQDSNKVE
CSEPQSQILE TPRASSRSPK SPAASRSTPA PVTRKASLLP LQLLRRSSVR PGVVVPRVRI
SKAPAPTFQP ERAASKGNTK DSIYLQIPKW RYKEAKEEKR KAEEAEKKRQ AEAQKEKRAP
RWRKRT
