HBB_COLLI
ID HBB_COLLI Reviewed; 146 AA.
AC P11342;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1989, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Hemoglobin subunit beta;
DE AltName: Full=Beta-globin;
DE AltName: Full=Hemoglobin beta chain;
GN Name=HBB;
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932;
RN [1]
RP PROTEIN SEQUENCE.
RX PubMed=1930630; DOI=10.1007/bf01024777;
RA Sultana C., Abbasi A., Zaidi Z.H.;
RT "Primary structure of hemoglobin beta-chain from Columba livia (gray wild
RT pigeon).";
RL J. Protein Chem. 10:145-149(1991).
CC -!- FUNCTION: Involved in oxygen transport from the lung to the various
CC peripheral tissues.
CC -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC -!- TISSUE SPECIFICITY: Red blood cells.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR PIR; A61432; HBPY.
DR PDB; 2R80; X-ray; 1.44 A; B/D=1-146.
DR PDB; 3DHR; X-ray; 2.00 A; B/D/F/H=1-146.
DR PDB; 3MJU; X-ray; 3.50 A; B=1-146.
DR PDBsum; 2R80; -.
DR PDBsum; 3DHR; -.
DR PDBsum; 3MJU; -.
DR AlphaFoldDB; P11342; -.
DR SMR; P11342; -.
DR STRING; 8932.XP_005507431.1; -.
DR eggNOG; KOG3378; Eukaryota.
DR EvolutionaryTrace; P11342; -.
DR GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR CDD; cd08925; Hb-beta-like; 1.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002337; Hemoglobin_b.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00814; BETAHAEM.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Heme; Iron; Metal-binding;
KW Oxygen transport; Transport.
FT CHAIN 1..146
FT /note="Hemoglobin subunit beta"
FT /id="PRO_0000052933"
FT BINDING 63
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT BINDING 92
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
FT HELIX 5..17
FT /evidence="ECO:0007829|PDB:2R80"
FT HELIX 20..34
FT /evidence="ECO:0007829|PDB:2R80"
FT HELIX 36..45
FT /evidence="ECO:0007829|PDB:2R80"
FT HELIX 51..56
FT /evidence="ECO:0007829|PDB:2R80"
FT HELIX 58..76
FT /evidence="ECO:0007829|PDB:2R80"
FT TURN 77..79
FT /evidence="ECO:0007829|PDB:2R80"
FT HELIX 81..84
FT /evidence="ECO:0007829|PDB:2R80"
FT HELIX 86..94
FT /evidence="ECO:0007829|PDB:2R80"
FT HELIX 101..118
FT /evidence="ECO:0007829|PDB:2R80"
FT HELIX 119..121
FT /evidence="ECO:0007829|PDB:2R80"
FT HELIX 124..141
FT /evidence="ECO:0007829|PDB:2R80"
FT TURN 142..145
FT /evidence="ECO:0007829|PDB:3DHR"
SQ SEQUENCE 146 AA; 16153 MW; 3F9698269D2F06FD CRC64;
VHWSAEEKQL ITSIWGKVNV ADCGAEALAR LLIVYPWTQR FFSSFGNLSS ATAISGNPNV
KAHGKKVLTS FGDAVKNLDN IKGTFAQLSE LHCDKLHVDP ENFRLLGDIL VIILAAHFGK
DFTPECQAAW QKLVRVVAHA LARKYH
