HBB_COTJA
ID HBB_COTJA Reviewed; 146 AA.
AC P30893;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Hemoglobin subunit beta;
DE AltName: Full=Beta-globin;
DE AltName: Full=Hemoglobin beta chain;
GN Name=HBB;
OS Coturnix japonica (Japanese quail) (Coturnix coturnix japonica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Perdicinae; Coturnix.
OX NCBI_TaxID=93934;
RN [1]
RP PROTEIN SEQUENCE.
RC TISSUE=Erythrocyte;
RX PubMed=8471178; DOI=10.1515/bchm3.1993.374.1-6.111;
RA Eguchi Y., Nakashima Y., Takei H.;
RT "Amino-acid sequence of the alpha D- and beta-polypeptide chains of the
RT Japanese quail hemoglobin.";
RL Biol. Chem. Hoppe-Seyler 374:111-116(1993).
CC -!- FUNCTION: Involved in oxygen transport from the lung to the various
CC peripheral tissues.
CC -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC -!- TISSUE SPECIFICITY: Red blood cells.
CC -!- MISCELLANEOUS: This beta chain is from both the minor and the major
CC components, which have been called the Q-I the Q-II component,
CC respectively.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
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DR PIR; S29169; S29169.
DR PDB; 3MJP; X-ray; 2.76 A; B/D=1-146.
DR PDBsum; 3MJP; -.
DR AlphaFoldDB; P30893; -.
DR SMR; P30893; -.
DR Proteomes; UP000694412; Unplaced.
DR GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR CDD; cd08925; Hb-beta-like; 1.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002337; Hemoglobin_b.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00814; BETAHAEM.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Heme; Iron; Metal-binding;
KW Oxygen transport; Reference proteome; Transport.
FT CHAIN 1..146
FT /note="Hemoglobin subunit beta"
FT /id="PRO_0000052935"
FT BINDING 63
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT BINDING 92
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
FT HELIX 7..15
FT /evidence="ECO:0007829|PDB:3MJP"
FT HELIX 20..34
FT /evidence="ECO:0007829|PDB:3MJP"
FT HELIX 36..45
FT /evidence="ECO:0007829|PDB:3MJP"
FT HELIX 53..56
FT /evidence="ECO:0007829|PDB:3MJP"
FT HELIX 60..75
FT /evidence="ECO:0007829|PDB:3MJP"
FT TURN 76..79
FT /evidence="ECO:0007829|PDB:3MJP"
FT HELIX 81..93
FT /evidence="ECO:0007829|PDB:3MJP"
FT TURN 94..96
FT /evidence="ECO:0007829|PDB:3MJP"
FT HELIX 101..115
FT /evidence="ECO:0007829|PDB:3MJP"
FT HELIX 119..121
FT /evidence="ECO:0007829|PDB:3MJP"
FT HELIX 124..140
FT /evidence="ECO:0007829|PDB:3MJP"
FT TURN 141..145
FT /evidence="ECO:0007829|PDB:3MJP"
SQ SEQUENCE 146 AA; 16335 MW; CE323D1ECB278A28 CRC64;
VHWSAEEKQL ITGLWGKVNV AECGAEALAR LLIVYPWTQR FFASFGNLSS PTAILGNPMV
RAHGKKVLTS FGDAVKNLDN IKNTFSQLSE LHCDKLHVDP ENFRLLGDIL IIVLAAHFTK
DFTPECQAAW QKLVRVVAHA LARKYH
