ID   HBB_CYPCA               Reviewed;         147 AA.
AC   P02139; Q9PRW6; Q9PRW7;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Hemoglobin subunit beta-A/B;
DE   AltName: Full=Hemoglobin beta-A/B chain;
DE   AltName: Full=Hemoglobin subunit beta-1/2;
OS   Cyprinus carpio (Common carp).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Cyprinus.
OX   NCBI_TaxID=7962;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=7450680;
RA   Grujic-Injac B., Braunitzer G., Stangl A.;
RT   "Hemoglobins, XXXV. The sequence of the beta A- and beta B-Chains of the
RT   hemoglobins of the carp (Cyprinus carpio L.).";
RL   Hoppe-Seyler's Z. Physiol. Chem. 361:1629-1639(1980).
RN   [2]
RP   PROTEIN SEQUENCE OF 1-40.
RX   PubMed=8014260; DOI=10.1007/bf00714576;
RA   Ohkudo N., Watabe S., Oshiro T., Takashima F., Nakajima H.;
RT   "Subunit structures of multiple hemoglobins in carp.";
RL   J. Comp. Physiol. B 164:88-88(1994).
CC   -!- FUNCTION: Involved in oxygen transport from gills to the various
CC       peripheral tissues.
CC   -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC   -!- TISSUE SPECIFICITY: Red blood cells.
CC   -!- POLYMORPHISM: There are two alleles. The sequence shown is that of
CC       beta-A. {ECO:0000269|PubMed:7450680}.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   PIR; A02459; HBCAA.
DR   AlphaFoldDB; P02139; -.
DR   SMR; P02139; -.
DR   Proteomes; UP000694384; Unplaced.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd08925; Hb-beta-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002337; Hemoglobin_b.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00814; BETAHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..147
FT                   /note="Hemoglobin subunit beta-A/B"
FT                   /id="PRO_0000052943"
FT   BINDING         63
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT   BINDING         92
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT   VARIANT         13
FT                   /note="A -> G (in beta-B chain)"
FT                   /evidence="ECO:0000269|PubMed:7450680"
FT   VARIANT         41
FT                   /note="F -> Y (in beta-B chain)"
FT                   /evidence="ECO:0000269|PubMed:7450680"
FT   VARIANT         122
FT                   /note="G -> A (in beta-B chain)"
FT                   /evidence="ECO:0000269|PubMed:7450680"
FT   VARIANT         143
FT                   /note="K -> C (in beta-B chain)"
FT                   /evidence="ECO:0000269|PubMed:7450680"
FT   CONFLICT        26
FT                   /note="E -> Q (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        31
FT                   /note="C -> R (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   147 AA;  16262 MW;  464BD37A04658956 CRC64;
     VEWTDAERSA IIALWGKLNP DELGPEALAR CLIVYPWTQR FFASYGNLSS PAAIMGNPKV
     AAHGRTVEGG LMRAIKDMDN IKATYAPLSV MHSEKLHVDP DNFRLLADCI TVCAAMKFGP
     SGFSPNVQEA WQKFLSVVVN ALKRQYH