ID   AN34A_RAT               Reviewed;         495 AA.
AC   Q5BJT1;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Ankyrin repeat domain-containing protein 34A;
GN   Name=Ankrd34a;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-315, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- PTM: Methylated at Gln-15 by N6AMT1. {ECO:0000250|UniProtKB:Q69YU3}.
CC   -!- SIMILARITY: Belongs to the ANKRD34 family. {ECO:0000305}.
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DR   EMBL; BC091343; AAH91343.1; -; mRNA.
DR   RefSeq; NP_001020151.1; NM_001024980.1.
DR   RefSeq; XP_006233015.1; XM_006232953.3.
DR   RefSeq; XP_008759505.1; XM_008761283.2.
DR   AlphaFoldDB; Q5BJT1; -.
DR   SMR; Q5BJT1; -.
DR   STRING; 10116.ENSRNOP00000053081; -.
DR   iPTMnet; Q5BJT1; -.
DR   PhosphoSitePlus; Q5BJT1; -.
DR   PaxDb; Q5BJT1; -.
DR   PRIDE; Q5BJT1; -.
DR   Ensembl; ENSRNOT00000043535; ENSRNOP00000053081; ENSRNOG00000033741.
DR   Ensembl; ENSRNOT00000113092; ENSRNOP00000095983; ENSRNOG00000033741.
DR   GeneID; 295283; -.
DR   KEGG; rno:295283; -.
DR   UCSC; RGD:1308412; rat.
DR   CTD; 284615; -.
DR   RGD; 1308412; Ankrd34a.
DR   eggNOG; ENOG502QT4A; Eukaryota.
DR   GeneTree; ENSGT00390000012355; -.
DR   HOGENOM; CLU_042805_0_0_1; -.
DR   InParanoid; Q5BJT1; -.
DR   OMA; PGNLCPD; -.
DR   OrthoDB; 466691at2759; -.
DR   PhylomeDB; Q5BJT1; -.
DR   TreeFam; TF331155; -.
DR   PRO; PR:Q5BJT1; -.
DR   Proteomes; UP000002494; Chromosome 2.
DR   Bgee; ENSRNOG00000033741; Expressed in frontal cortex and 11 other tissues.
DR   Genevisible; Q5BJT1; RN.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR042637; AN34A/B/C.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   PANTHER; PTHR24156; PTHR24156; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   SMART; SM00248; ANK; 4.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
PE   1: Evidence at protein level;
KW   ANK repeat; Methylation; Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..495
FT                   /note="Ankyrin repeat domain-containing protein 34A"
FT                   /id="PRO_0000319101"
FT   REPEAT          4..33
FT                   /note="ANK 1"
FT   REPEAT          37..72
FT                   /note="ANK 2"
FT   REPEAT          76..106
FT                   /note="ANK 3"
FT   REPEAT          110..139
FT                   /note="ANK 4"
FT   REGION          147..495
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        147..163
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        166..180
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        201..217
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        219..234
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        370..389
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        426..457
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         15
FT                   /note="N5-methylglutamine"
FT                   /evidence="ECO:0000250|UniProtKB:Q69YU3"
FT   MOD_RES         315
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
SQ   SEQUENCE   495 AA;  52456 MW;  9014352C1FCE7F26 CRC64;
     MLHTEGHALL RAVGQGKLRL ARLLLEGGAY VNEGDAQGET ALMAACRARY DDPQNKARMV
     RYLLEQGADP NIADRLGRTA LMHACAGGGG AAVASLLLAH GADPSVRDHA GASALVHALD
     RGDRETLATL LDACKAKGTE VIIITTDTSP SGTKKTRQYL NSPPSPGVED PAPAPPSPGV
     CTSPSEVQLQ TAGGGRGLLS PRAQEEEEKR DVFEFPLPKS PDDPSPSEPL PKPPRHPPKP
     LKRLNSEPWG LVAPPQPVPP AEGRPGLERL AAEFNGLTLT GRPRLSRRHS TEGPEDPPPW
     AEKVTGGGPL SRRNTAPEAQ ESGLPSGLRQ KLSRMESVEL DTPGHFCPDS PESSRLSLER
     RRYSASPLTL PPAGSVSSPR QSQESLPGAV SPLSGRRRSP GLLERRGSGT LLLDHISQTR
     PGFLPPLNVS PHPPIPDIRP QPGGRAPSLP APPHSGAPGS PRTKRKLVRR HSMQTEQIRL
     LGGFQSLGGP GEPGR