AN34B_HUMAN
ID AN34B_HUMAN Reviewed; 514 AA.
AC A5PLL1; B2RPH1; Q68D79;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 3.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Ankyrin repeat domain-containing protein 34B;
GN Name=ANKRD34B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT SER-156.
RC TISSUE=Rectum tumor;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus {ECO:0000250}.
CC -!- PTM: Phosphorylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ANKRD34 family. {ECO:0000305}.
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DR EMBL; CR749535; CAH18341.1; -; mRNA.
DR EMBL; AC008434; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC137441; AAI37442.1; -; mRNA.
DR EMBL; BC137442; AAI37443.1; -; mRNA.
DR EMBL; BC142957; AAI42958.1; -; mRNA.
DR CCDS; CCDS34194.1; -.
DR RefSeq; NP_001004441.2; NM_001004441.2.
DR RefSeq; XP_006714662.1; XM_006714599.3.
DR RefSeq; XP_011541668.1; XM_011543366.2.
DR RefSeq; XP_011541671.1; XM_011543369.2.
DR AlphaFoldDB; A5PLL1; -.
DR SMR; A5PLL1; -.
DR BioGRID; 131001; 2.
DR STRING; 9606.ENSP00000339802; -.
DR iPTMnet; A5PLL1; -.
DR PhosphoSitePlus; A5PLL1; -.
DR BioMuta; ANKRD34B; -.
DR EPD; A5PLL1; -.
DR MassIVE; A5PLL1; -.
DR PaxDb; A5PLL1; -.
DR PeptideAtlas; A5PLL1; -.
DR PRIDE; A5PLL1; -.
DR Antibodypedia; 49135; 82 antibodies from 17 providers.
DR DNASU; 340120; -.
DR Ensembl; ENST00000338682.8; ENSP00000339802.3; ENSG00000189127.8.
DR GeneID; 340120; -.
DR KEGG; hsa:340120; -.
DR MANE-Select; ENST00000338682.8; ENSP00000339802.3; NM_001004441.3; NP_001004441.2.
DR UCSC; uc003kgw.4; human.
DR CTD; 340120; -.
DR GeneCards; ANKRD34B; -.
DR HGNC; HGNC:33736; ANKRD34B.
DR HPA; ENSG00000189127; Tissue enriched (brain).
DR MIM; 618581; gene.
DR neXtProt; NX_A5PLL1; -.
DR OpenTargets; ENSG00000189127; -.
DR PharmGKB; PA162376576; -.
DR VEuPathDB; HostDB:ENSG00000189127; -.
DR eggNOG; ENOG502QRZ2; Eukaryota.
DR GeneTree; ENSGT00390000012355; -.
DR HOGENOM; CLU_042805_0_0_1; -.
DR InParanoid; A5PLL1; -.
DR OMA; RHQSIDI; -.
DR OrthoDB; 466691at2759; -.
DR PhylomeDB; A5PLL1; -.
DR TreeFam; TF331155; -.
DR PathwayCommons; A5PLL1; -.
DR BioGRID-ORCS; 340120; 21 hits in 1067 CRISPR screens.
DR GenomeRNAi; 340120; -.
DR Pharos; A5PLL1; Tbio.
DR PRO; PR:A5PLL1; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; A5PLL1; protein.
DR Bgee; ENSG00000189127; Expressed in nucleus accumbens and 46 other tissues.
DR ExpressionAtlas; A5PLL1; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR042637; AN34A/B/C.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR PANTHER; PTHR24156; PTHR24156; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13637; Ank_4; 1.
DR SMART; SM00248; ANK; 4.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 2: Evidence at transcript level;
KW ANK repeat; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..514
FT /note="Ankyrin repeat domain-containing protein 34B"
FT /id="PRO_0000319102"
FT REPEAT 9..38
FT /note="ANK 1"
FT REPEAT 42..79
FT /note="ANK 2"
FT REPEAT 83..113
FT /note="ANK 3"
FT REPEAT 117..146
FT /note="ANK 4"
FT REGION 220..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 263
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3UUF8"
FT MOD_RES 272
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q3UUF8"
FT MOD_RES 296
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3UUF8"
FT VARIANT 156
FT /note="L -> S (in dbSNP:rs32857)"
FT /evidence="ECO:0000269|PubMed:17974005"
FT /id="VAR_038952"
FT CONFLICT 429
FT /note="R -> G (in Ref. 1; CAH18341)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 514 AA; 56414 MW; 65B1CC8F92E0730E CRC64;
MDEGMEISSE GNSLIKAVHQ SRLRLTRLLL EGGAYINESN DRGETPLMIA CKTKHVDHQS
VSKAKMVKYL LENNADPNIQ DKSGKTALMH ACLEKAGPEV VSLLLKSGAD LSLQDHSSYS
ALVYAINSED TETLKVLLSA CKAKGKEVII ITTAKLPCGK HTTKQYLNMP PVDIDGCHSP
ATCTTPSEID IKTASSPLSH SSETELTLFG FKDLELAGSN DDTWDPGSPV RKPALAPKGP
KLPHAPPWVK SPPLLMHQNR VASLQEELQD ITPEEELSYK TNGLALSKRF ITRHQSIDVK
DTAHLLRAFD QASSRKMSYD EINCQSYLSE GNQQCIEVPV DQDPDSNQTI FASTLRSIVQ
KRNLGANHYS SDSQLSAGLT PPTSEDGKAL IGKKKILSPS PSQLSESKEL LENIPPGPLS
RRNHAVLERR GSGAFPLDHS VTQTRQGFLP PLNVNSHPPI SDINVNNKIC SLLSCGQKVL
MPTVPIFPKE FKSKKMLLRR QSLQTEQIKQ LVNF
