AN34B_MOUSE
ID AN34B_MOUSE Reviewed; 508 AA.
AC Q3UUF8; Q4VA01; Q8BVH7;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Ankyrin repeat domain-containing protein 34B;
DE AltName: Full=Dendritic cell progenitor protein of 58 kDa {ECO:0000303|PubMed:15358210};
GN Name=Ankrd34b; Synonyms=Dp58;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Olfactory bulb, and Spinal cord;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY, INDUCTION, AND PHOSPHORYLATION.
RX PubMed=15358210; DOI=10.1016/j.bbrc.2004.06.106;
RA Al-Shaibi N., Ghosh S.K.;
RT "A novel phosphoprotein is induced during bone marrow commitment to
RT dendritic cells.";
RL Biochem. Biophys. Res. Commun. 321:26-30(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=16452087; DOI=10.1074/mcp.t500041-mcp200;
RA Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.;
RT "Comprehensive identification of phosphorylation sites in postsynaptic
RT density preparations.";
RL Mol. Cell. Proteomics 5:914-922(2006).
RN [5]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, AND PHOSPHORYLATION.
RX PubMed=17485271; DOI=10.2741/2284;
RA Al-Shaibi N., King M.W., Duong T., Ghosh S.K.;
RT "DP58, an inducible myeloid protein, is constitutively expressed in murine
RT neuronal nuclei.";
RL Front. Biosci. 12:2947-2956(2007).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-260; THR-269 AND SER-293, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17485271}. Nucleus
CC {ECO:0000269|PubMed:17485271}.
CC -!- TISSUE SPECIFICITY: Specifically and constitutively expressed in brain
CC (at protein level). {ECO:0000269|PubMed:17485271}.
CC -!- INDUCTION: Up-regulated in bone marrow upon differentiation (at protein
CC level). {ECO:0000269|PubMed:15358210, ECO:0000269|PubMed:17485271}.
CC -!- PTM: Phosphorylated. {ECO:0000269|PubMed:15358210,
CC ECO:0000269|PubMed:17485271}.
CC -!- SIMILARITY: Belongs to the ANKRD34 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH96609.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK078203; BAC37170.1; -; mRNA.
DR EMBL; AK138465; BAE23669.1; -; mRNA.
DR EMBL; BC096609; AAH96609.1; ALT_FRAME; mRNA.
DR EMBL; BC119312; AAI19313.1; -; mRNA.
DR EMBL; BC119314; AAI19315.1; -; mRNA.
DR CCDS; CCDS26681.1; -.
DR RefSeq; NP_780664.2; NM_175455.4.
DR RefSeq; XP_011242940.1; XM_011244638.2.
DR RefSeq; XP_017170979.1; XM_017315490.1.
DR AlphaFoldDB; Q3UUF8; -.
DR SMR; Q3UUF8; -.
DR STRING; 10090.ENSMUSP00000054330; -.
DR iPTMnet; Q3UUF8; -.
DR PhosphoSitePlus; Q3UUF8; -.
DR MaxQB; Q3UUF8; -.
DR PaxDb; Q3UUF8; -.
DR PRIDE; Q3UUF8; -.
DR ProteomicsDB; 282095; -.
DR Antibodypedia; 49135; 82 antibodies from 17 providers.
DR DNASU; 218440; -.
DR Ensembl; ENSMUST00000061594; ENSMUSP00000054330; ENSMUSG00000045034.
DR Ensembl; ENSMUST00000168871; ENSMUSP00000126289; ENSMUSG00000045034.
DR GeneID; 218440; -.
DR KEGG; mmu:218440; -.
DR UCSC; uc007rkn.2; mouse.
DR CTD; 340120; -.
DR MGI; MGI:2443245; Ankrd34b.
DR VEuPathDB; HostDB:ENSMUSG00000045034; -.
DR eggNOG; ENOG502QRZ2; Eukaryota.
DR GeneTree; ENSGT00390000012355; -.
DR HOGENOM; CLU_042805_0_0_1; -.
DR InParanoid; Q3UUF8; -.
DR OMA; RHQSIDI; -.
DR OrthoDB; 466691at2759; -.
DR PhylomeDB; Q3UUF8; -.
DR TreeFam; TF331155; -.
DR BioGRID-ORCS; 218440; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q3UUF8; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q3UUF8; protein.
DR Bgee; ENSMUSG00000045034; Expressed in medial vestibular nucleus and 69 other tissues.
DR ExpressionAtlas; Q3UUF8; baseline and differential.
DR Genevisible; Q3UUF8; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR042637; AN34A/B/C.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR PANTHER; PTHR24156; PTHR24156; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13637; Ank_4; 1.
DR SMART; SM00248; ANK; 4.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 1: Evidence at protein level;
KW ANK repeat; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..508
FT /note="Ankyrin repeat domain-containing protein 34B"
FT /id="PRO_0000319103"
FT REPEAT 9..38
FT /note="ANK 1"
FT REPEAT 42..79
FT /note="ANK 2"
FT REPEAT 83..113
FT /note="ANK 3"
FT REPEAT 117..146
FT /note="ANK 4"
FT REGION 157..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 260
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 269
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 293
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 401
FT /note="S -> F (in Ref. 1; BAC37170)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 508 AA; 55417 MW; A8CC87D45E3F01BF CRC64;
MDEGSEVSTD GNSLIKAVHQ SRLRLTRLLL EGGAYINESN DRGETPLMIA CKTKHVDQQS
VGRAKMVKYL LENSADPNIQ DKSGKSALMH ACLERAGPEV VSLLLKSGAD LSLQDHSGYS
ALVYAINAED RDTLKVLLSA CQAKGKEVII ITTAKSPSGR HTTQHHLNMP PADMDGSHPP
ATPSEIDIKT ASLPLSYSSE TDLTLFGFKD KELCGGSDNT WDPDSPPRKP VIATNGPKLS
QAPAWIKSTP SLKHQARVAS LQEELQDITP EEEIAYKTNA LALSKRFITR HQSIDVKDTA
HLLRAFDQVN SRKMSYDEIN YHSLFPEGSQ TSVEIPTDRD PDSNQIFAST LKSIVQKRNS
GANHYSSDSQ LAEGVTPPTV EDGKAAKKKI FAPSPSLLSG SKELVEPAPP GPLSRRNHAV
LERRGSGAFP LDHSLAQSRP GFLPPLNVNP HPPITDIGVN NKICGLLSCG QKALMPTAPI
FPKEFKTKKM LLRRQSLQTE QIKQLVNF
