ID   HBB_LEPEU               Reviewed;         147 AA.
AC   P08535;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Hemoglobin subunit beta;
DE   AltName: Full=Beta-globin;
DE   AltName: Full=Hemoglobin beta chain;
GN   Name=HBB;
OS   Lepus europaeus (European hare).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Lepus.
OX   NCBI_TaxID=9983;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3615213; DOI=10.1093/nar/15.14.5899;
RA   Pauplin Y., Rech J.;
RT   "Nucleotide sequence of hare adult beta-globin gene with flanking
RT   regions.";
RL   Nucleic Acids Res. 15:5899-5899(1987).
CC   -!- FUNCTION: Involved in oxygen transport from the lung to the various
CC       peripheral tissues.
CC   -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC   -!- TISSUE SPECIFICITY: Red blood cells.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   EMBL; Y00347; CAA68429.1; -; Genomic_DNA.
DR   PIR; A27101; A27101.
DR   PDB; 3LQD; X-ray; 2.80 A; B/D=2-147.
DR   PDBsum; 3LQD; -.
DR   AlphaFoldDB; P08535; -.
DR   SMR; P08535; -.
DR   EvolutionaryTrace; P08535; -.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd08925; Hb-beta-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002337; Hemoglobin_b.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00814; BETAHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Acetylation; Heme; Iron; Metal-binding; Oxygen transport;
KW   Phosphoprotein; S-nitrosylation; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:P02086"
FT   CHAIN           2..147
FT                   /note="Hemoglobin subunit beta"
FT                   /id="PRO_0000052990"
FT   BINDING         64
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT   BINDING         93
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT   MOD_RES         2
FT                   /note="N-acetylvaline"
FT                   /evidence="ECO:0000250|UniProtKB:P02086"
FT   MOD_RES         13
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:P68871"
FT   MOD_RES         45
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P68871"
FT   MOD_RES         60
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P68871"
FT   MOD_RES         83
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P68871"
FT   MOD_RES         94
FT                   /note="S-nitrosocysteine"
FT                   /evidence="ECO:0000250|UniProtKB:P68871"
FT   MOD_RES         145
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P68871"
FT   HELIX           6..16
FT                   /evidence="ECO:0007829|PDB:3LQD"
FT   TURN            21..23
FT                   /evidence="ECO:0007829|PDB:3LQD"
FT   HELIX           24..35
FT                   /evidence="ECO:0007829|PDB:3LQD"
FT   HELIX           37..46
FT                   /evidence="ECO:0007829|PDB:3LQD"
FT   HELIX           52..57
FT                   /evidence="ECO:0007829|PDB:3LQD"
FT   HELIX           59..77
FT                   /evidence="ECO:0007829|PDB:3LQD"
FT   HELIX           79..81
FT                   /evidence="ECO:0007829|PDB:3LQD"
FT   HELIX           82..95
FT                   /evidence="ECO:0007829|PDB:3LQD"
FT   HELIX           102..119
FT                   /evidence="ECO:0007829|PDB:3LQD"
FT   HELIX           120..122
FT                   /evidence="ECO:0007829|PDB:3LQD"
FT   HELIX           125..143
FT                   /evidence="ECO:0007829|PDB:3LQD"
FT   TURN            144..146
FT                   /evidence="ECO:0007829|PDB:3LQD"
SQ   SEQUENCE   147 AA;  16062 MW;  9047D46AB5992FDB CRC64;
     MVHLSGEEKS AVTALWGKVN VEEVGGETLG RLLVVYPWTQ RFFESFGDLS TASAVMGNPK
     VKAHGKKVLA AFSEGLSHLD NLKGTFAKLS ELHCDKLHVD PENFRLLGNV LVIVLSHHFG
     KEFTPQVQAA YQKVVAGVAN ALAHKYH