ID   HBB_LITCT               Reviewed;         140 AA.
AC   P02135;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-1987, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Hemoglobin subunit beta;
DE   AltName: Full=Beta-globin;
DE   AltName: Full=Hemoglobin beta chain;
GN   Name=HBB;
OS   Lithobates catesbeianus (American bullfrog) (Rana catesbeiana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Lithobates.
OX   NCBI_TaxID=8400;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=3487542; DOI=10.1016/s0021-9258(19)83909-1;
RA   Tam L.T., Gray G.P., Riggs A.F.;
RT   "The hemoglobins of the bullfrog Rana catesbeiana. The structure of the
RT   beta chain of component C and the role of the alpha chain in the formation
RT   of intermolecular disulfide bonds.";
RL   J. Biol. Chem. 261:8290-8294(1986).
CC   -!- FUNCTION: The beta chain is a component of adult hemoglobins B. And C.
CC   -!- SUBUNIT: Heterotetramer of either two alpha-B chains or two alpha-C
CC       chains and two beta chains.
CC   -!- MISCELLANEOUS: Hemoglobin C tetramers polymerize by the formation of
CC       disulfide bonds. The deoxy tetramers of hemoglobin B and C associate to
CC       form molecules believed to be trimers (B+2C) of very low oxygen
CC       affinity.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   PIR; A02455; HBFGC.
DR   PRIDE; P02135; -.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd08925; Hb-beta-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002337; Hemoglobin_b.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00814; BETAHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW   Transport.
FT   CHAIN           1..140
FT                   /note="Hemoglobin subunit beta"
FT                   /id="PRO_0000053086"
FT   BINDING         57
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT   BINDING         86
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
SQ   SEQUENCE   140 AA;  15425 MW;  01963DA6056020E5 CRC64;
     GGSDVSAFLA KVDKRAVGGE ALARLLIVYP WTQRYFSTFG NLGSADAISH NSKVLAHGQR
     VLDSIEEGLK HPZBLKAYYA KLSERHSGEL HVDPANFYRL GNVLITVMAR HFHEEFTPEL
     QCALHSSFCA VGEALAKGYH